Summary of DRD2
The D2 receptor prevents potentiation of glutamate responses in the ventral tegmental area (VTA) neurons. Repeated cocaine treatment causes loss of D2 dopamine receptor functional responses, which is one mechanism of cocaine-induced pleasure/addiction.
It's better to have this gene increased
most of the time.
Exceptions:
psychosis
,
schizophrenia
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
DShort name:
2Alternative name(s):
Dopamine D2 receptor- RS1076560 (DRD2) ??
- RS1079596 (DRD2) ??
- RS1079597 (DRD2) ??
- RS1079727 (DRD2) ??
- RS11214606 (DRD2) ??
- RS1125394 (DRD2) ??
- RS12364283 (DRD2) ??
- RS1799732 (DRD2) ??
- RS1799978 (DRD2) ??
- RS1800496 (DRD2) ??
- RS1800497 (DRD2) ??
- RS1800498 (DRD2) ??
- RS1801028 (DRD2) ??
- RS2242592 (DRD2) ??
- RS2283265 (DRD2) ??
- RS2514218 (DRD2) ??
- RS2734839 (DRD2) ??
- RS4436578 (DRD2) ??
- RS4648317 (DRD2) ??
- RS4648319 (DRD2) ??
- RS6275 (DRD2) ??
- RS6277 (DRD2) ??
- RS6279 (DRD2) ??
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Top Gene-Substance Interactions
DRD2 Interacts with These Diseases
| Disease | Score |
Fixes
If you have less or less active D2 receptors, it means you want to increase DRD2 receptors or increase DRD2 activation such as precursors for dopamine.
Natural Fixes:
- Light (R),
- Calorie restriction/Fasting (R),
- Exercise (R),
- Mucuna (by increasing dopamine),
- Forskolin (R),
- Curcumin (R),
- CDP-choline (R),
- Blueberry (R),
- Spirulina (R)
Stay away from:
- Low protein, high carb diets (R)
- Opioids decrease the DRD2 receptor
- Psychostimulants decrease the DRD2 receptor
- High fat or high sugar diet decrease the DRD2 receptor
- Cocaine, which will decrease dopamine D2 receptors (R)
- Alcohol If your homocysteine is higher (say over 9), you should lower it with supplements like methyl folate or methyl B12, because homocysteine can reduce the receptor function (R).
- You might not want to take supplements like Yohimbine because it blocks the D2 receptor (R). You want to be very careful about taking anti-psychotics because this gene is associated with increased weight gain.
Fixes Advanced
Drugs that increase DRD2 receptors (at least in animals):
Substances That Increase DRD2
| Substances | Interaction | Organism | Category |
Substances That Decrease DRD2
| Substances | Interaction | Organism | Category |
Advanced Summary
Stimulation of D2 receptors in T cells has been shown to inhibit activated T cell receptor (TCR)-induced cell proliferation and secretion of IL-2, IFN-³, and IL-4 (R).
DRD2 receptors are important for modafinil induced wakefulness and wakefulness in general (R, R2).
Reduced dopamine D2 receptors correlate with poor behavioral control across species (R, R2, R3, R4).
Dopamine receptor which inhibits adenylyl cyclase.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Dopamine Binding
- Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go
- Drug Binding
- Identical Protein Binding
- Potassium Channel Regulator Activity
Biological Processes:
- Acid Secretion
- Activation Of Protein Kinase Activity
- Adenohypophysis Development
- Adenylate Cyclase-Inhibiting Dopamine Receptor Signaling Pathway
- Adult Walking Behavior
- Arachidonic Acid Secretion
- Associative Learning
- Auditory Behavior
- Axonogenesis
- Behavioral Response To Cocaine
- Behavioral Response To Ethanol
- Branching Morphogenesis Of A Nerve
- Cellular Calcium Ion Homeostasis
- Cerebral Cortex Gabaergic Interneuron Migration
- Chemical Synaptic Transmission, Postsynaptic
- Circadian Regulation Of Gene Expression
- Dopamine Metabolic Process
- Feeding Behavior
- G-Protein Coupled Receptor Internalization
- Grooming Behavior
- Intracellular Signal Transduction
- Locomotory Behavior
- Long-Term Memory
- Negative Regulation Of Adenylate Cyclase Activity
- Negative Regulation Of Blood Pressure
- Negative Regulation Of Cell Migration
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Circadian Sleep/Wake Cycle, Sleep
- Negative Regulation Of Cytosolic Calcium Ion Concentration
- Negative Regulation Of Dopamine Receptor Signaling Pathway
- Negative Regulation Of Dopamine Secretion
- Negative Regulation Of Innate Immune Response
- Negative Regulation Of Insulin Secretion
- Negative Regulation Of Protein Kinase B Signaling
- Negative Regulation Of Protein Secretion
- Negative Regulation Of Synaptic Transmission, Glutamatergic
- Negative Regulation Of Voltage-Gated Calcium Channel Activity
- Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure
- Neuron-Neuron Synaptic Transmission
- Orbitofrontal Cortex Development
- Peristalsis
- Phosphatidylinositol Metabolic Process
- Phospholipase C-Activating Dopamine Receptor Signaling Pathway
- Pigmentation
- Positive Regulation Of Cytokinesis
- Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-Activating G-Protein Coupled Signaling Pathway
- Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Glial Cell-Derived Neurotrophic Factor Secretion
- Positive Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
- Positive Regulation Of Growth Hormone Secretion
- Positive Regulation Of Long-Term Synaptic Potentiation
- Positive Regulation Of Multicellular Organism Growth
- Positive Regulation Of Neuroblast Proliferation
- Positive Regulation Of Receptor Internalization
- Positive Regulation Of Renal Sodium Excretion
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Urine Volume
- Prepulse Inhibition
- Protein Localization
- Regulation Of Camp Metabolic Process
- Regulation Of Dopamine Secretion
- Regulation Of Dopamine Uptake Involved In Synaptic Transmission
- Regulation Of Heart Rate
- Regulation Of Locomotion Involved In Locomotory Behavior
- Regulation Of Long-Term Neuronal Synaptic Plasticity
- Regulation Of Phosphoprotein Phosphatase Activity
- Regulation Of Potassium Ion Transport
- Regulation Of Sodium Ion Transport
- Regulation Of Synapse Structural Plasticity
- Regulation Of Synaptic Transmission, Gabaergic
- Release Of Sequestered Calcium Ion Into Cytosol
- Response To Amphetamine
- Response To Axon Injury
- Response To Cocaine
- Response To Histamine
- Response To Hypoxia
- Response To Iron Ion
- Response To Light Stimulus
- Response To Morphine
- Response To Nicotine
- Response To Toxic Substance
- Sensory Perception Of Smell
- Striatum Development
- Synapse Assembly
- Synaptic Transmission, Dopaminergic
- Temperature Homeostasis
- Visual Learning
- Wnt Signaling Pathway
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