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  3. DRD2

DRD2 (Dopamine receptor D2)

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Summary of DRD2

The DRD2 gene codes for dopamine receptor D2 (DRD2). DRD2 is one of multiple receptors that determine the activity of the chemical messenger dopamine [R, R].

DRD2 plays a role in [R, R]:

  • Movement
  • Reward and reinforcement 
  • Learning and memory

DRD2 variants have been linked to [R, R]:

  • Movement disorders
  • Substance abuse 
  • Addiction
  • Schizophrenia
  • Bipolar disorder
  • PTSD

Some types of drugs for schizophrenia function by blocking DRD2 [R].

It's better to have this gene increased most of the time. Exceptions: psychosis , schizophrenia
0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

D

Short name:

2

Alternative name(s):

Dopamine D2 receptor

DRD2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1076560 (DRD2) ??
  2. RS1079596 (DRD2) ??
  3. RS1079597 (DRD2) ??
  4. RS1079727 (DRD2) ??
  5. RS11214606 (DRD2) ??
  6. RS1125394 (DRD2) ??
  7. RS12364283 (DRD2) ??
  8. RS1799732 (DRD2) ??
  9. RS1799978 (DRD2) ??
  10. RS1800496 (DRD2) ??
  11. RS1800497 (DRD2) ??
  12. RS1800498 (DRD2) ??
  13. RS1801028 (DRD2) ??
  14. RS2242592 (DRD2) ??
  15. RS2283265 (DRD2) ??
  16. RS2514218 (DRD2) ??
  17. RS2734839 (DRD2) ??
  18. RS4436578 (DRD2) ??
  19. RS4648317 (DRD2) ??
  20. RS4648319 (DRD2) ??
  21. RS6275 (DRD2) ??
  22. RS6277 (DRD2) ??
  23. RS6279 (DRD2) ??

Top Gene-Substance Interactions

DRD2 Interacts with These Diseases

Disease Score

Fixes

If you have less or less active D2 receptors, it means you want to increase DRD2 receptors or increase DRD2 activation such as precursors for dopamine.

Natural Fixes: 

  • Light (R),
  • Calorie restriction/Fasting (R),
  • Exercise (R), 
  • Mucuna (by increasing dopamine), 
  • Forskolin (R),
  • Curcumin (R),
  • CDP-choline (R),
  • Blueberry (R),
  • Spirulina (R)

Stay away from: 

  • Low protein, high carb diets (R)
  • Opioids decrease the DRD2 receptor
  • Psychostimulants decrease the DRD2 receptor
  • High fat or high sugar diet decrease the DRD2 receptor
  • Cocaine, which will decrease dopamine D2 receptors (R)
  • Alcohol If your homocysteine is higher (say over 9), you should lower it with supplements like methyl folate or methyl B12, because homocysteine can reduce the receptor function (R).
  • You might not want to take supplements like Yohimbine because it blocks the D2 receptor (R). You want to be very careful about taking anti-psychotics because this gene is associated with increased weight gain.

Fixes Advanced

Drugs that increase DRD2 receptors (at least in animals):

  • Nicotine (R) - although DRD2 receptors decrease after withdrawal.
  • Memantine (R),
  • Ketamine (R), 
  • Tianeptine (R),
  • Aripiprazole (R),
  • Phenylpiracetam (R),
  • Low dose antipsychotics at night (R),
  • Bromocriptine (R)
  • Modafinil seems to activate DRD2 in some regions (R, R2).

Substances That Increase DRD2

Substances Interaction Organism Category

Substances That Decrease DRD2

Substances Interaction Organism Category

Advanced Summary

Stimulation of D2 receptors in T cells has been shown to inhibit activated T cell receptor (TCR)-induced cell proliferation and secretion of IL-2, IFN-³, and IL-4 (R).

DRD2 receptors are important for modafinil induced wakefulness and wakefulness in general (R, R2).

Reduced dopamine D2 receptors correlate with poor behavioral control across species (R, R2, R3, R4).

Dopamine receptor which inhibits adenylyl cyclase.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • ER-alpha
  • GR
  • GR-alpha
  • GR-beta
  • Egr-1
  • NF-kappaB1
  • Sp1
  • c-Rel
  • p300

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction

Molecular Function:

  • Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go
  • Drug Binding
  • Potassium Channel Regulator Activity
  • Dopamine Binding
  • Identical Protein Binding

Biological Processes:

  • Temperature Homeostasis
  • Response To Hypoxia
  • Synaptic Transmission, Dopaminergic
  • Response To Amphetamine
  • Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure
  • Regulation Of Heart Rate
  • Regulation Of Sodium Ion Transport
  • G-Protein Coupled Receptor Internalization
  • Positive Regulation Of Neuroblast Proliferation
  • Positive Regulation Of Receptor Internalization
  • Cellular Calcium Ion Homeostasis
  • Negative Regulation Of Adenylate Cyclase Activity
  • Adenylate Cyclase-Inhibiting Dopamine Receptor Signaling Pathway
  • Neuron-Neuron Synaptic Transmission
  • Axonogenesis
  • Synapse Assembly
  • Sensory Perception Of Smell
  • Long-Term Memory
  • Grooming Behavior
  • Locomotory Behavior
  • Adult Walking Behavior
  • Feeding Behavior
  • Protein Localization
  • Negative Regulation Of Cell Proliferation
  • Associative Learning
  • Visual Learning
  • Response To Light Stimulus
  • Response To Toxic Substance
  • Response To Iron Ion
  • Regulation Of Dopamine Secretion
  • Wnt Signaling Pathway
  • Striatum Development
  • Orbitofrontal Cortex Development
  • Cerebral Cortex Gabaergic Interneuron Migration
  • Adenohypophysis Development
  • Negative Regulation Of Cell Migration
  • Peristalsis
  • Regulation Of Camp Metabolic Process
  • Auditory Behavior
  • Activation Of Protein Kinase Activity
  • Regulation Of Synaptic Transmission, Gabaergic
  • Positive Regulation Of Cytokinesis
  • Circadian Regulation Of Gene Expression
  • Negative Regulation Of Dopamine Secretion
  • Response To Histamine
  • Response To Nicotine
  • Intracellular Signal Transduction
  • Positive Regulation Of Urine Volume
  • Positive Regulation Of Renal Sodium Excretion
  • Positive Regulation Of Multicellular Organism Growth
  • Response To Cocaine
  • Negative Regulation Of Circadian Sleep/Wake Cycle, Sleep
  • Dopamine Metabolic Process
  • Regulation Of Potassium Ion Transport
  • Response To Morphine
  • Pigmentation
  • Regulation Of Phosphoprotein Phosphatase Activity
  • Positive Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
  • Negative Regulation Of Blood Pressure
  • Negative Regulation Of Innate Immune Response
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Phosphatidylinositol Metabolic Process
  • Negative Regulation Of Insulin Secretion
  • Acid Secretion
  • Behavioral Response To Cocaine
  • Behavioral Response To Ethanol
  • Regulation Of Long-Term Neuronal Synaptic Plasticity
  • Response To Axon Injury
  • Branching Morphogenesis Of A Nerve
  • Arachidonic Acid Secretion
  • Negative Regulation Of Protein Secretion
  • Release Of Sequestered Calcium Ion Into Cytosol
  • Negative Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-Activating G-Protein Coupled Signaling Pathway
  • Regulation Of Dopamine Uptake Involved In Synaptic Transmission
  • Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission
  • Regulation Of Synapse Structural Plasticity
  • Negative Regulation Of Protein Kinase B Signaling
  • Negative Regulation Of Synaptic Transmission, Glutamatergic
  • Positive Regulation Of Growth Hormone Secretion
  • Prepulse Inhibition
  • Phospholipase C-Activating Dopamine Receptor Signaling Pathway
  • Negative Regulation Of Dopamine Receptor Signaling Pathway
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Regulation Of Locomotion Involved In Locomotory Behavior
  • Chemical Synaptic Transmission, Postsynaptic
  • Positive Regulation Of Glial Cell-Derived Neurotrophic Factor Secretion
  • Positive Regulation Of Long-Term Synaptic Potentiation
  • Negative Regulation Of Voltage-Gated Calcium Channel Activity

Drug Bank:

  • Amisulpride
  • Ergoloid Mesylate
  • Flupentixol
  • Lurasidone
  • Paliperidone
  • Pipotiazine
  • Rotigotine
  • Zuclopenthixol
  • Acetophenazine
  • Alizapride
  • Amantadine
  • Amoxapine
  • Amphetamine
  • Aripiprazole
  • Asenapine
  • Brexpiprazole
  • Bromocriptine
  • Bromopride
  • Buspirone
  • Cariprazine
  • Chlorpromazine
  • Chlorprothixene
  • Cinnarizine
  • Clozapine
  • Domperidone
  • Dopamine
  • Doxepin
  • Droperidol
  • Ergotamine
  • Fluspirilene
  • Haloperidol
  • Iloperidone
  • Imipramine
  • Ketamine
  • Lisuride
  • Loxapine
  • Maprotiline
  • Memantine
  • Methotrimeprazine
  • Metoclopramide
  • Mianserin
  • Minaprine
  • Mirtazapine
  • Nortriptyline
  • Olanzapine
  • Pergolide
  • Perphenazine
  • Pimozide
  • Pramipexole
  • Promazine
  • Promethazine
  • Propiomazine
  • Quetiapine
  • Remoxipride
  • Risperidone
  • Sertindole
  • Sulpiride
  • Tetrabenazine
  • Thioproperazine
  • Thioridazine
  • Thiothixene
  • Triflupromazine
  • Trimipramine
  • Yohimbine
  • Ziprasidone
  • Acepromazine
  • Apomorphine
  • Cabergoline
  • Desipramine
  • Fluphenazine
  • Levodopa
  • Mesoridazine
  • Molindone
  • Prochlorperazine
  • Ropinirole
  • Trifluoperazine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| seven transmembrane helix receptor| D2| A306_14340| AS27_14242| AS28_06502| CB1_000303006| D(2)| d215| D(2) dopamine receptor| D2 dopamine receptor| D(2) dopamine receptor isoform long| D2DR| D(2)-like dopamine receptor| D2R| D2 receptor| dopamine D2-like receptor| dopamine D2 receptor| dopamine D2 receptor short isoform| dopamine receptor 2| dopamine receptor 2 protein| dopamine receptor D2 isoform| Drd-2| drd2-a| drd2-b| EH28_04108| H920_07562| I79_004402| M91_04741| M959_01841| N300_14312| N301_02268| N302_11152| N303_13005| N305_04144| N306_12469| N307_03098| N308_11001| N309_12385| N310_11492| N311_09279| N312_00917| N320_02507| N321_14155| N322_05089| N324_10172| N325_03104| N326_02982| N327_11427| N328_08560| N329_10449| N330_08244| N331_11775| N332_05567| N333_13087| N334_14219| N335_10404| N336_11417| N339_12060| N340_10103| N341_11832| PAL_GLEAN10009098| PANDA_018403| TREES_T100013191| UY3_07710| Y1Q_012570| Y956_12609| Z169_08827| drd2

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