Summary of DRD2
The DRD2 gene codes for dopamine receptor D2 (DRD2). DRD2 is one of multiple receptors that determine the activity of the chemical messenger dopamine [R, R].
- Movement
- Reward and reinforcement
- Learning and memory
DRD2 variants have been linked to [R, R]:
- Movement disorders
- Substance abuse
- Addiction
- Schizophrenia
- Bipolar disorder
- PTSD
Some types of drugs for schizophrenia function by blocking DRD2 [R].
It's better to have this gene increased
most of the time.
Exceptions:
psychosis
,
schizophrenia
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
DShort name:
2Alternative name(s):
Dopamine D2 receptor- RS1076560 (DRD2) ??
- RS1079596 (DRD2) ??
- RS1079597 (DRD2) ??
- RS1079727 (DRD2) ??
- RS11214606 (DRD2) ??
- RS1125394 (DRD2) ??
- RS12364283 (DRD2) ??
- RS1799732 (DRD2) ??
- RS1799978 (DRD2) ??
- RS1800496 (DRD2) ??
- RS1800497 (DRD2) ??
- RS1800498 (DRD2) ??
- RS1801028 (DRD2) ??
- RS2242592 (DRD2) ??
- RS2283265 (DRD2) ??
- RS2514218 (DRD2) ??
- RS2734839 (DRD2) ??
- RS4436578 (DRD2) ??
- RS4648317 (DRD2) ??
- RS4648319 (DRD2) ??
- RS6275 (DRD2) ??
- RS6277 (DRD2) ??
- RS6279 (DRD2) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
DRD2 Interacts with These Diseases
| Disease | Score |
Fixes
If you have less or less active D2 receptors, it means you want to increase DRD2 receptors or increase DRD2 activation such as precursors for dopamine.
Natural Fixes:
- Light (R),
- Calorie restriction/Fasting (R),
- Exercise (R),
- Mucuna (by increasing dopamine),
- Forskolin (R),
- Curcumin (R),
- CDP-choline (R),
- Blueberry (R),
- Spirulina (R)
Stay away from:
- Low protein, high carb diets (R)
- Opioids decrease the DRD2 receptor
- Psychostimulants decrease the DRD2 receptor
- High fat or high sugar diet decrease the DRD2 receptor
- Cocaine, which will decrease dopamine D2 receptors (R)
- Alcohol If your homocysteine is higher (say over 9), you should lower it with supplements like methyl folate or methyl B12, because homocysteine can reduce the receptor function (R).
- You might not want to take supplements like Yohimbine because it blocks the D2 receptor (R). You want to be very careful about taking anti-psychotics because this gene is associated with increased weight gain.
Fixes Advanced
Drugs that increase DRD2 receptors (at least in animals):
Substances That Increase DRD2
| Substances | Interaction | Organism | Category |
Substances That Decrease DRD2
| Substances | Interaction | Organism | Category |
Advanced Summary
Stimulation of D2 receptors in T cells has been shown to inhibit activated T cell receptor (TCR)-induced cell proliferation and secretion of IL-2, IFN-³, and IL-4 (R).
DRD2 receptors are important for modafinil induced wakefulness and wakefulness in general (R, R2).
Reduced dopamine D2 receptors correlate with poor behavioral control across species (R, R2, R3, R4).
Dopamine receptor which inhibits adenylyl cyclase.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go
- Drug Binding
- Potassium Channel Regulator Activity
- Dopamine Binding
- Identical Protein Binding
Biological Processes:
- Temperature Homeostasis
- Response To Hypoxia
- Synaptic Transmission, Dopaminergic
- Response To Amphetamine
- Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure
- Regulation Of Heart Rate
- Regulation Of Sodium Ion Transport
- G-Protein Coupled Receptor Internalization
- Positive Regulation Of Neuroblast Proliferation
- Positive Regulation Of Receptor Internalization
- Cellular Calcium Ion Homeostasis
- Negative Regulation Of Adenylate Cyclase Activity
- Adenylate Cyclase-Inhibiting Dopamine Receptor Signaling Pathway
- Neuron-Neuron Synaptic Transmission
- Axonogenesis
- Synapse Assembly
- Sensory Perception Of Smell
- Long-Term Memory
- Grooming Behavior
- Locomotory Behavior
- Adult Walking Behavior
- Feeding Behavior
- Protein Localization
- Negative Regulation Of Cell Proliferation
- Associative Learning
- Visual Learning
- Response To Light Stimulus
- Response To Toxic Substance
- Response To Iron Ion
- Regulation Of Dopamine Secretion
- Wnt Signaling Pathway
- Striatum Development
- Orbitofrontal Cortex Development
- Cerebral Cortex Gabaergic Interneuron Migration
- Adenohypophysis Development
- Negative Regulation Of Cell Migration
- Peristalsis
- Regulation Of Camp Metabolic Process
- Auditory Behavior
- Activation Of Protein Kinase Activity
- Regulation Of Synaptic Transmission, Gabaergic
- Positive Regulation Of Cytokinesis
- Circadian Regulation Of Gene Expression
- Negative Regulation Of Dopamine Secretion
- Response To Histamine
- Response To Nicotine
- Intracellular Signal Transduction
- Positive Regulation Of Urine Volume
- Positive Regulation Of Renal Sodium Excretion
- Positive Regulation Of Multicellular Organism Growth
- Response To Cocaine
- Negative Regulation Of Circadian Sleep/Wake Cycle, Sleep
- Dopamine Metabolic Process
- Regulation Of Potassium Ion Transport
- Response To Morphine
- Pigmentation
- Regulation Of Phosphoprotein Phosphatase Activity
- Positive Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
- Negative Regulation Of Blood Pressure
- Negative Regulation Of Innate Immune Response
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Phosphatidylinositol Metabolic Process
- Negative Regulation Of Insulin Secretion
- Acid Secretion
- Behavioral Response To Cocaine
- Behavioral Response To Ethanol
- Regulation Of Long-Term Neuronal Synaptic Plasticity
- Response To Axon Injury
- Branching Morphogenesis Of A Nerve
- Arachidonic Acid Secretion
- Negative Regulation Of Protein Secretion
- Release Of Sequestered Calcium Ion Into Cytosol
- Negative Regulation Of Cytosolic Calcium Ion Concentration
- Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-Activating G-Protein Coupled Signaling Pathway
- Regulation Of Dopamine Uptake Involved In Synaptic Transmission
- Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission
- Regulation Of Synapse Structural Plasticity
- Negative Regulation Of Protein Kinase B Signaling
- Negative Regulation Of Synaptic Transmission, Glutamatergic
- Positive Regulation Of Growth Hormone Secretion
- Prepulse Inhibition
- Phospholipase C-Activating Dopamine Receptor Signaling Pathway
- Negative Regulation Of Dopamine Receptor Signaling Pathway
- Positive Regulation Of Erk1 And Erk2 Cascade
- Regulation Of Locomotion Involved In Locomotory Behavior
- Chemical Synaptic Transmission, Postsynaptic
- Positive Regulation Of Glial Cell-Derived Neurotrophic Factor Secretion
- Positive Regulation Of Long-Term Synaptic Potentiation
- Negative Regulation Of Voltage-Gated Calcium Channel Activity
Drug Bank:
- Amisulpride
- Ergoloid Mesylate
- Flupentixol
- Lurasidone
- Paliperidone
- Pipotiazine
- Rotigotine
- Zuclopenthixol
- Acetophenazine
- Alizapride
- Amantadine
- Amoxapine
- Amphetamine
- Aripiprazole
- Asenapine
- Brexpiprazole
- Bromocriptine
- Bromopride
- Buspirone
- Cariprazine
- Chlorpromazine
- Chlorprothixene
- Cinnarizine
- Clozapine
- Domperidone
- Dopamine
- Doxepin
- Droperidol
- Ergotamine
- Fluspirilene
- Haloperidol
- Iloperidone
- Imipramine
- Ketamine
- Lisuride
- Loxapine
- Maprotiline
- Memantine
- Methotrimeprazine
- Metoclopramide
- Mianserin
- Minaprine
- Mirtazapine
- Nortriptyline
- Olanzapine
- Pergolide
- Perphenazine
- Pimozide
- Pramipexole
- Promazine
- Promethazine
- Propiomazine
- Quetiapine
- Remoxipride
- Risperidone
- Sertindole
- Sulpiride
- Tetrabenazine
- Thioproperazine
- Thioridazine
- Thiothixene
- Triflupromazine
- Trimipramine
- Yohimbine
- Ziprasidone
- Acepromazine
- Apomorphine
- Cabergoline
- Desipramine
- Fluphenazine
- Levodopa
- Mesoridazine
- Molindone
- Prochlorperazine
- Ropinirole
- Trifluoperazine