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  3. DHFR

DHFR (Dihydrofolate reductase)

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Summary of DHFR

This gene encodes an enzyme that plays a part in folate metabolism (R). 

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The Function of DHFR

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.

Protein names

Recommended name:

Dihydrofolate reductase

DHFR SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1643649 (DHFR) ??
  2. RS1650697 (DHFR) ??

Top Gene-Substance Interactions

DHFR Interacts with These Diseases

Disease Score

Substances That Increase DHFR

Substances Interaction Organism Category

Substances That Decrease DHFR

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Megaloblastic anemia due to dihydrofolate reductase deficiencyFrom UniProt: Megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD): An inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms. [MIM:613839]

     From NCBI Gene: Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014] From UniProt: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Pax-3
  • C/EBPalpha
  • Sp1
  • IRF-1
  • E2F-1
  • E2F-4

Tissue specificity:

Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Disease
  • Folate biosynthesis
  • One carbon pool by folate

Molecular Function:

  • Dihydrofolate Reductase Activity
  • Drug Binding
  • Folate Reductase Activity
  • Folic Acid Binding
  • Methotrexate Binding
  • Mrna Binding
  • Nadph Binding

Biological Processes:

  • Axon Regeneration
  • Dihydrofolate Metabolic Process
  • Folic Acid Metabolic Process
  • G1/S Transition Of Mitotic Cell Cycle
  • Glycine Biosynthetic Process
  • Nucleotide Biosynthetic Process
  • One-Carbon Metabolic Process
  • Oxidation-Reduction Process
  • Positive Regulation Of Nitric-Oxide Synthase Activity
  • Regulation Of Removal Of Superoxide Radicals
  • Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
  • Response To Methotrexate
  • Tetrahydrobiopterin Biosynthetic Process
  • Tetrahydrofolate Biosynthetic Process
  • Tetrahydrofolate Metabolic Process

Drug Bank:

  • Gentamicin
  • Pralatrexate
  • Pemetrexed
  • Proguanil
  • Pyrimethamine
  • Trimethoprim
  • Trimetrexate
  • Methotrexate
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13853| AS27_09956| AS28_04428| CB1_000917039| CG14887 gene product from transcript CG14887-RB| CG14887-PA| CG14887-PB| Dhfr1| DHFRP1| Dhfr-PA| Dhfr-PB| Dihydrofolate reductase 1 (active)| dihydrofolate reductase-like protein| dihydrofolate reductase variant 1| dihydrofolate reductase variant 2| dihydrofolate reductase variant 3| Dmel_CG14887| DYR| H920_01337| I79_015631| M959_04289| N300_13740| N301_05773| N302_01077| N303_13997| N305_07153| N306_12815| N307_08908| N308_15535| N309_02994| N312_11411| N322_08025| N324_04909| N327_12077| N329_02871| N330_01990| N331_04929| N332_14011| N333_10763| N334_07753| N335_02901| N336_10323| N339_09694| N340_07566| N341_05795| PAL_GLEAN10024944| TREES_T100019308| UY3_13344| Y1Q_017983| Y956_13588| Z169_01784| dhfr

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