Summary of CYP1B1
Part of the Phase I reactions of drug metabolism.
The CYP1B1 gene provides instructions for producing an enzyme that is a member of the cytochrome P450 family of enzymes. These enzymes are involved in many processes in the body, such as assisting with reactions that break down drugs and produce certain fats (lipids). The CYP1B1 enzyme participates in biochemical reactions in which an oxygen atom is added to other molecules. The CYP1B1 enzyme is active in many tissues, including structures of the eye. The function of the CYP1B1 enzyme in the development of the eye is unclear, but it may play a role in forming structures at the front of the eye and may also be involved in a process that regulates the secretion of fluid inside the eye.
Regulated by the aryl hydrocarbon receptor.
The Function of CYP1B1
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
Protein names
Recommended name:
Cytochrome P450 1B1Short name:
CYPIB1- RS10012 (CYP1B1) ??
- RS1056827 (CYP1B1) ??
- RS1056836 (CYP1B1) ??
- RS1056837 (CYP1B1) ??
- RS1800440 (CYP1B1) ??
- RS2617266 (CYP1B1) ??
- RS9282671 (CYP1B1) ??
- RS9341266 (CYP1B1) ??
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Top Gene-Substance Interactions
CYP1B1 Interacts with These Diseases
Disease | Score |
Substances That Increase CYP1B1
Substances | Interaction | Organism | Category |
Substances That Decrease CYP1B1
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in many tissues.
Gene Pathways:
Induction:
By polycyclic aromatic hydrocarbons (PAH) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Enzyme Regulation:
Enzyme activity is increased by liposomes containing anionic phospholipids, phosphatidic acid and cardiolipin. Inhibited by naringenin with an IC(50) of 5 uM.
Molecular Function:
- Aromatase Activity
- Heme Binding
- Iron Ion Binding
- Monooxygenase Activity
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
- Oxygen Binding
Biological Processes:
- Angiogenesis
- Arachidonic Acid Metabolic Process
- Blood Vessel Morphogenesis
- Cell Adhesion
- Cellular Aromatic Compound Metabolic Process
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Organic Cyclic Compound
- Collagen Fibril Organization
- Endothelial Cell-Cell Adhesion
- Endothelial Cell Migration
- Epoxygenase P450 Pathway
- Estrogen Metabolic Process
- Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
- Membrane Lipid Catabolic Process
- Negative Regulation Of Cell Adhesion Mediated By Integrin
- Negative Regulation Of Cell Migration
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Nitric Oxide Biosynthetic Process
- Omega-Hydroxylase P450 Pathway
- Oxidation-Reduction Process
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Jak-Stat Cascade
- Positive Regulation Of Vascular Endothelial Growth Factor Production
- Regulation Of Reactive Oxygen Species Metabolic Process
- Response To Toxic Substance
- Retinal Blood Vessel Morphogenesis
- Retinal Metabolic Process
- Retinol Metabolic Process
- Steroid Metabolic Process
- Sterol Metabolic Process
- Toxin Metabolic Process
- Trabecular Meshwork Development
- Visual Perception
- Xenobiotic Metabolic Process
Drug Bank:
- Erlotinib
- Arsenic Trioxide
- Biotin
- Caffeine
- Dasatinib
- Daunorubicin
- Dexamethasone
- Docetaxel
- Doxorubicin
- Estrone
- Flutamide
- Ketoconazole
- Melatonin
- Mitoxantrone
- Omeprazole
- Paclitaxel
- Phenobarbital
- Primaquine
- Procarbazine
- Progesterone
- Propofol
- Testosterone
- Theophylline
- Lansoprazole
- Amodiaquine
- Clozapine
- Estradiol
- Oxaliplatin
- Tamoxifen