The Function of BMP2
Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Protein names
Recommended name:
Bone morphogenetic protein 2Short name:
BMP-2Alternative name(s):
Bone morphogenetic protein 2ABMP-2A
- RS1884302 (BMP2) ??
- RS2273074 (BMP2) ??
- RS235756 (BMP2) ??
- RS235770 (BMP2) ??
- RS6054512 (BMP2) ??
- RS6085820 (BMP2) ??
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Top Gene-Substance Interactions
BMP2 Interacts with These Diseases
Disease | Score |
Substances That Increase BMP2
Substances | Interaction | Organism | Category |
Substances That Decrease BMP2
Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Hemochromatosis type 1Brachydactyly type A2
From NCBI Gene: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016] From UniProt: Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Gene Pathways:
Molecular Function:
- Retinol Dehydrogenase Activity
- Receptor Binding
- Cytokine Activity
- Transforming Growth Factor Beta Receptor Binding
- Phosphatase Activator Activity
- Co-Receptor Binding
- Smad Binding
- Protein Heterodimerization Activity
- Bmp Receptor Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Activation Of Mapk Activity
- Skeletal System Development
- Osteoblast Differentiation
- Branching Involved In Ureteric Bud Morphogenesis
- Response To Hypoxia
- In Utero Embryonic Development
- Epithelial To Mesenchymal Transition
- Positive Regulation Of Protein Phosphorylation
- Positive Regulation Of Endothelial Cell Proliferation
- Chondrocyte Differentiation
- Bmp Signaling Pathway Involved In Heart Induction
- Atrioventricular Valve Morphogenesis
- Endocardial Cushion Morphogenesis
- Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development
- Proteoglycan Metabolic Process
- Regulation Of Transcription, Dna-Templated
- Protein Phosphorylation
- Inflammatory Response
- Notch Signaling Pathway
- Cell-Cell Signaling
- Heart Development
- Negative Regulation Of Cell Proliferation
- Embryo Development
- Animal Organ Morphogenesis
- Positive Regulation Of Gene Expression
- Positive Regulation Of Epithelial To Mesenchymal Transition
- Positive Regulation Of Pathway-Restricted Smad Protein Phosphorylation
- Negative Regulation Of Steroid Biosynthetic Process
- Positive Regulation Of Phosphatase Activity
- Telencephalon Development
- Telencephalon Regionalization
- Positive Regulation Of Wnt Signaling Pathway
- Bone Mineralization
- Positive Regulation Of Cell Migration
- Positive Regulation Of Bone Mineralization
- Bmp Signaling Pathway
- Protein Destabilization
- Negative Regulation Of Aldosterone Biosynthetic Process
- Positive Regulation Of Osteoblast Proliferation
- Cardiocyte Differentiation
- Embryonic Heart Tube Anterior/Posterior Pattern Specification
- Bone Mineralization Involved In Bone Maturation
- Growth
- Odontogenesis Of Dentin-Containing Tooth
- Positive Regulation Of Odontogenesis
- Regulation Of Odontogenesis Of Dentin-Containing Tooth
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Mapk Cascade
- Negative Regulation Of Insulin-Like Growth Factor Receptor Signaling Pathway
- Cell Fate Commitment
- Positive Regulation Of Fat Cell Differentiation
- Positive Regulation Of Neuron Differentiation
- Positive Regulation Of Osteoblast Differentiation
- Positive Regulation Of Ossification
- Negative Regulation Of Cell Cycle
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Astrocyte Differentiation
- Mesenchymal Cell Differentiation
- Inner Ear Development
- Negative Regulation Of Calcium-Independent Cell-Cell Adhesion
- Cardiac Muscle Cell Differentiation
- Cardiac Muscle Tissue Morphogenesis
- Pericardium Development
- Corticotropin Hormone Secreting Cell Differentiation
- Thyroid-Stimulating Hormone-Secreting Cell Differentiation
- Cardiac Epithelial To Mesenchymal Transition
- Pathway-Restricted Smad Protein Phosphorylation
- Smad Protein Signal Transduction
- Mesenchyme Development
- Positive Regulation Of Wnt Signaling Pathway By Bmp Signaling Pathway
- Positive Regulation Of Cartilage Development
- Positive Regulation Of Erk1 And Erk2 Cascade
- Cellular Response To Organic Cyclic Compound
- Cellular Response To Bmp Stimulus
- Mesenchymal Cell Proliferation Involved In Ureteric Bud Development
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Positive Regulation Of P38mapk Cascade
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Cellular Response To Chemical Stimulus
- Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Cortisol Biosynthetic Process
- Negative Regulation Of Cardiac Muscle Cell Differentiation