• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. BMP2

BMP2 (Bone morphogenetic protein 2)

Loading...

The Function of BMP2

Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Bone morphogenetic protein 2

Short name:

BMP-2

Alternative name(s):

Bone morphogenetic protein 2A
BMP-2A

BMP2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1884302 (BMP2) ??
  2. RS2273074 (BMP2) ??
  3. RS235756 (BMP2) ??
  4. RS235770 (BMP2) ??
  5. RS6054512 (BMP2) ??
  6. RS6085820 (BMP2) ??

Top Gene-Substance Interactions

BMP2 Interacts with These Diseases

Disease Score

Substances That Increase BMP2

Substances Interaction Organism Category

Substances That Decrease BMP2

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Hemochromatosis type 1Brachydactyly type A2

     From NCBI Gene: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016] From UniProt: Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • Nkx2-5
  • MEF-2A
  • Sox9
  • Sox5

Tissue specificity:

Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Gene Pathways:

  • Pathways in cancer
  • Signal Transduction
  • Basal cell carcinoma
  • Hedgehog signaling pathway
  • Cytokine-cytokine receptor interaction
  • TGF-beta signaling pathway
  • Extracellular matrix organization

Molecular Function:

  • Retinol Dehydrogenase Activity
  • Receptor Binding
  • Cytokine Activity
  • Transforming Growth Factor Beta Receptor Binding
  • Phosphatase Activator Activity
  • Co-Receptor Binding
  • Smad Binding
  • Protein Heterodimerization Activity
  • Bmp Receptor Binding

Biological Processes:

  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Activation Of Mapk Activity
  • Skeletal System Development
  • Osteoblast Differentiation
  • Branching Involved In Ureteric Bud Morphogenesis
  • Response To Hypoxia
  • In Utero Embryonic Development
  • Epithelial To Mesenchymal Transition
  • Positive Regulation Of Protein Phosphorylation
  • Positive Regulation Of Endothelial Cell Proliferation
  • Chondrocyte Differentiation
  • Bmp Signaling Pathway Involved In Heart Induction
  • Atrioventricular Valve Morphogenesis
  • Endocardial Cushion Morphogenesis
  • Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development
  • Proteoglycan Metabolic Process
  • Regulation Of Transcription, Dna-Templated
  • Protein Phosphorylation
  • Inflammatory Response
  • Notch Signaling Pathway
  • Cell-Cell Signaling
  • Heart Development
  • Negative Regulation Of Cell Proliferation
  • Embryo Development
  • Animal Organ Morphogenesis
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Epithelial To Mesenchymal Transition
  • Positive Regulation Of Pathway-Restricted Smad Protein Phosphorylation
  • Negative Regulation Of Steroid Biosynthetic Process
  • Positive Regulation Of Phosphatase Activity
  • Telencephalon Development
  • Telencephalon Regionalization
  • Positive Regulation Of Wnt Signaling Pathway
  • Bone Mineralization
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Bone Mineralization
  • Bmp Signaling Pathway
  • Protein Destabilization
  • Negative Regulation Of Aldosterone Biosynthetic Process
  • Positive Regulation Of Osteoblast Proliferation
  • Cardiocyte Differentiation
  • Embryonic Heart Tube Anterior/Posterior Pattern Specification
  • Bone Mineralization Involved In Bone Maturation
  • Growth
  • Odontogenesis Of Dentin-Containing Tooth
  • Positive Regulation Of Odontogenesis
  • Regulation Of Odontogenesis Of Dentin-Containing Tooth
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Mapk Cascade
  • Negative Regulation Of Insulin-Like Growth Factor Receptor Signaling Pathway
  • Cell Fate Commitment
  • Positive Regulation Of Fat Cell Differentiation
  • Positive Regulation Of Neuron Differentiation
  • Positive Regulation Of Osteoblast Differentiation
  • Positive Regulation Of Ossification
  • Negative Regulation Of Cell Cycle
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Astrocyte Differentiation
  • Mesenchymal Cell Differentiation
  • Inner Ear Development
  • Negative Regulation Of Calcium-Independent Cell-Cell Adhesion
  • Cardiac Muscle Cell Differentiation
  • Cardiac Muscle Tissue Morphogenesis
  • Pericardium Development
  • Corticotropin Hormone Secreting Cell Differentiation
  • Thyroid-Stimulating Hormone-Secreting Cell Differentiation
  • Cardiac Epithelial To Mesenchymal Transition
  • Pathway-Restricted Smad Protein Phosphorylation
  • Smad Protein Signal Transduction
  • Mesenchyme Development
  • Positive Regulation Of Wnt Signaling Pathway By Bmp Signaling Pathway
  • Positive Regulation Of Cartilage Development
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Cellular Response To Organic Cyclic Compound
  • Cellular Response To Bmp Stimulus
  • Mesenchymal Cell Proliferation Involved In Ureteric Bud Development
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Positive Regulation Of P38mapk Cascade
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Cellular Response To Chemical Stimulus
  • Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Cortisol Biosynthetic Process
  • Negative Regulation Of Cardiac Muscle Cell Differentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_06417| Anapl_08995| AS27_11318| AS28_01676| BDA2| BMP-2| bmp2a| bmp2-a| BMP-2A| bmp2b| bmp2-b| bone morphogenetic protein 2a| bone morphogenetic protein 2b| bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A)| bone morphogenetic protein 2 preproprotein| bone morphoproteintic protein 2| CB1_000951022| D623_10032311| EGK_02657| GW7_04632| H920_16415| I79_000443| M91_03049| M959_01219| MDA_GLEAN10025052| N300_06358| N301_10986| N302_14365| N303_01207| N305_05016| N306_06633| N307_05864| N308_11910| N310_08506| N311_03889| N312_12849| N320_08142| N324_03680| N325_09088| N327_13427| N329_07308| N330_10788| N331_07656| N332_06382| N333_00849| N334_07951| N336_12489| N339_02170| N340_06295| N341_04835| PAL_GLEAN10024079| PANDA_014486| PsBMP2| TREES_T100018165| UY3_15567| xbmp2| xBMP-2| Y1Q_021479| Y956_14534| Z169_07352| bmp2

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved