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rs833061

Chromosome : 6 , Position: 43769749

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: C

Alternative Alleles: T

Associated Genes

VEGFA

MRPS18A

CAPN11

MRPL14

TMEM63B

GTPBP2

MAD2L1BP

RSPH9

POLH

XPO5

LRRC73

POLR1C

SLC29A1

YIPF3

DLK2

TJAP1

ABCC10

HSP90AB1

SPATS1

ZNF318

CRIP3

MYMX

SLC22A7

NFKBIE

SLC35B2

Traits

Trait	Variant	PMID	Author (year)
Haematocrit percentage	T	Unknown journal	UKB Neale v2 (2018)
Hematocrit	T	Cell	Chen MH (2020)
Hemoglobin	T	Cell	Vuckovic D (2020)
Hemoglobin concentration	T	Cell	Astle WJ (2016)
Red blood cell count	T	Cell	Astle WJ (2016)
Haemoglobin concentration	T	Unknown journal	UKB Neale v2 (2018)

Summary

[PMID 19761764] Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population

[PMID 19594543] Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer

[PMID 19875757] Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy

[PMID 20847577] Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Neovascular Age-Related Macular Degeneration in a Chinese Cohort

[PMID 22439647] The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure – one institution study

[PMID 22162628] Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes

[PMID 16613616] Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.

[PMID 17319747] Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk.

[PMID 17983459] Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients.

[PMID 18281657] VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.

[PMID 18378209] Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration.

[PMID 18650217] Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis.

[PMID 18780893] Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk.

[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II–endometriosis.

[PMID 19041064] Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease.

[PMID 19308252] Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation.

[PMID 19566948] Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

[PMID 19584152] Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis.

[PMID 19755511] The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.

[PMID 19835575] The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

[PMID 20389299] Pazopanib-induced hyperbilirubinemia is associated with Gilbert’s syndrome UGT1A1 polymorphism.

[PMID 21080079] Gene polymorphism of vascular endothelial growth factor -1154 G>A is associated with hypertensive nephropathy in a Hispanic population.

[PMID 21347390] Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.

[PMID 21362767] Interaction between smoking and polymorphism in the promoter region of the VEGFA gene is associated with ischemic heart disease and myocardial infarction in rheumatoid arthritis.

[PMID 21982816] Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.

[PMID 22139971] Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma.

[PMID 22307787] Pooled-analysis of the associations between three polymorphisms in the VEGF gene and age-related macular degeneration.

[PMID 22320189] Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.

[PMID 22429695] Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: differential effect of cigarette smoking.

[PMID 22521084] Role of Vascular Endothelial Growth Factor Polymorphisms in the Treatment Success in Patients with Wet Age-related Macular Degeneration.

[PMID 23073296] VEGF Polymorphisms are not associated with an Increased Risk of Developing Renal Cell Carcinoma in Spanish population

[PMID 23404364] Polymorphisms in the VEGFA promoter are associated with susceptibility to hepatocellular carcinoma by altering promoter activity

[PMID 22776467] Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes

[PMID 23511629] VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib

[PMID 24039754] The impact of polymorphic variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the risk and prognosis of portuguese patients with non-small cell lung cancer

[PMID 24353087] Assessment of the associations between three VEGF polymorphisms and risk of prostate cancer

[PMID 24623964] Candidate gene association study for diabetic retinopathy in Chinese patients with type 2 diabetes

[PMID 22925497] The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.

[PMID 23061744] Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C and +936T/C) with endometriosis: a meta-analysis.

[PMID 23064377] Influence of vascular endothelial growth factor single nucleotide polymorphisms on non-small cell lung cancer tumor angiogenesis.

[PMID 23264084] Positive association of the vascular endothelial growth factor-A +405 GG genotype and poor survival in stage I-II gastric cancer in the Northern Chinese population.

[PMID 24868559] The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

[PMID 25148899] Investigating the association of vascular endothelial growth factor polymorphisms with breast cancer: a Moroccan case-control study

[PMID 25139485] Single-nucleotide polymorphisms in the vascular endothelial growth factor pathway and outcomes of patients treated with first-line cytotoxic chemotherapy combined with bevacizumab for advanced colorectal cancer

[PMID 26075076] Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

[PMID 26264619] Vascular endothelial growth factor polymorphisms and a synchronized examination of plasma and tissue expression in epithelial ovarian cancers

[PMID 24971577] Vascular endothelial growth factor A (VEGFA) gene polymorphisms have an impact on survival in a subgroup of indolent patients with chronic lymphocytic leukemia

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