46 Whim syndrome is an acronym for a rare immunodeficiency disorder with each letter representing a predominant feature of the condition: (w) = warts; (h) = hypogammaglobulinemia; (i) = infections; and (m) = myelokathexis (retention of neutrophils in the bone marrow). symptoms usually begin in early childhood with recurrent bacterial infections such as respiratory infections and cellulitis. in later childhood, individuals develop widespread warts that often become persistent despite treatments that are normally effective. warts that involve the genital area may eventually cause cancer. it is caused by mutations in the cxcr4 gene and is inherited in an autosomal dominant manner. treatment may include medications that replace antibodies (intravenous immunoglobulin) or increase the number of neutrophils; vaccinations; and prophylactic antibiotics to reduce the risk of infections
Disease Interacts with Genes
Disease Interacts with Substances
Processes Associated With Trait
Molecular Function Associated With Trait
Biological Processes Associated With Trait
Pathways Associated With Trait
Symptoms Associated With Trait
Selected genes are highlighted in orange, bookmarked
genes are green
- Chemical increases gene,
- Chemical decreases gene,
- Chemical increases and decreases gene simultaneosly,
No arrows - gene doesn't interact with the chemical.
- Gene should be increased/decreased most of the time and the chemical does it.
- Gene should be increased/decreased most of the time but the chemical does the opposite.