46 Hereditary neuropathy with liability to pressure palsy (hnpp) is a disorder that affects peripheral nerves. this condition causes recurrent episodes of numbness, tingling, and/or loss of muscle function (palsy). an episode can last from several minutes to several months, but recovery is usually complete. repeated incidents, however, can cause permanent muscle weakness or loss of sensation. the most common problem sites involve nerves in wrists, elbows, and knees. symptoms usually begin during adolescence or early adulthood but may develop anytime from childhood to late adulthood. symptoms vary in severity; many people never realize they have the disorder, while some people experience prolonged disability. this condition is caused by the loss of one copy of the pmp22 gene or alterations within the gene. it is inherited in an autosomal dominant manner
Disease Interacts with Genes
Disease Interacts with Substances
Processes Associated With Trait
Molecular Function Associated With Trait
Biological Processes Associated With Trait
Selected genes are highlighted in orange, bookmarked
genes are green
- Chemical increases gene,
- Chemical decreases gene,
- Chemical increases and decreases gene simultaneosly,
No arrows - gene doesn't interact with the chemical.
- Gene should be increased/decreased most of the time and the chemical does it.
- Gene should be increased/decreased most of the time but the chemical does the opposite.