Osteolysis, Familial Expansile, also known as familial expansile osteolysis,is related to chromosome 16q22 deletion syndrome and myopia,and has symptoms including conductive hearing impairment, bone pain and thin bony cortex. An important gene associated with Osteolysis, Familial Expansile is TNFRSF11A (TNF Receptor Superfamily Member 11a), and among its related pathways are NF-kappa B signaling pathway and Rheumatoid arthritis. Affiliated tissues include bone and cortex, and related mousephenotypes are craniofacial and limbs/digits/tail

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