46 Progressive osseous heteroplasia is an inherited condition in which bone forms within skin and muscle tissue. bone that forms outside the skeleton is called heterotopic or ectopic bone. in this condition, ectopic bone formation begins in the deep layers of the skin (dermis and subcutaneous fat) and gradually moves into other tissues such as skeletal muscle and tendons. the bony lesions within the skin may be painful and may develop into open sores (ulcers). over time, joints can become involved, resulting in impaired mobility. this condition is caused by mutations in the gnas gene and is inherited in an autosomal dominant pattern
Disease Interacts with Genes
Disease Interacts with Substances
Processes Associated With Trait
Molecular Function Associated With Trait
Biological Processes Associated With Trait
Pathways Associated With Trait
Symptoms Associated With Trait
Selected genes are highlighted in orange, bookmarked
genes are green
- Chemical increases gene,
- Chemical decreases gene,
- Chemical increases and decreases gene simultaneosly,
No arrows - gene doesn't interact with the chemical.
- Gene should be increased/decreased most of the time and the chemical does it.
- Gene should be increased/decreased most of the time but the chemical does the opposite.