46 Progressive osseous heteroplasia is an inherited condition in which bone forms within skin and muscle tissue. bone that forms outside the skeleton is called heterotopic or ectopic bone. in this condition, ectopic bone formation begins in the deep layers of the skin (dermis and subcutaneous fat) and gradually moves into other tissues such as skeletal muscle and tendons. the bony lesions within the skin may be painful and may develop into open sores (ulcers). over time, joints can become involved, resulting in impaired mobility. this condition is caused by mutations in the gnas gene and is inherited in an autosomal dominant pattern

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