Neural Tube Defects, Folate-Sensitive, also known as folate-sensitive susceptibility to neural tube defects,is related to neural tube defects and occipital encephalocele,and has symptoms including abnormality of metabolism/homeostasis and spinal dysraphism. An important gene associated with Neural Tube Defects, Folate-Sensitive is MTHFD1 (Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase And Formyltetrahydrofolate Synthetase 1), and among its related pathways are Folate Metabolism and Carbon metabolism. Affiliated tissues include heart