46 Dopamine beta hydroxylase deficiency is a disease which affects the body’s ability to regulate blood pressure and body temperature. symptoms typically begin in late childhood and include vomiting, dehydration, low blood pressure, especially upon standing (orthostatic hypotension), and low blood sugar levels (hypoglycemia). low blood pressure can also cause dizziness, blurred vision, and difficulty exercising. some people have experienced drooping eyelids (ptosis), muscle pain, and weakness. dopamine beta hydroxylase deficiency is caused by mutationin the dbh gene and is inherited in an autosomal recessivemanner. diagnosis is based on blood tests showing high dopamine levels and low norepinephrine levels. treatment with a synthetic form of norepinephrine can reduce hypotension.
Disease Interacts with Genes
Disease Interacts with Substances
Processes Associated With Disease
Molecular Function Associated With Disease
Biological Processes Associated With Disease
Pathways Associated With Disease
Symptoms Associated With Disease
Selected genes are highlighted in orange, bookmarked
genes are green
- Chemical increases gene,
- Chemical decreases gene,
- Chemical increases and decreases gene simultaneosly,
No arrows - gene doesn't interact with the chemical.
- Gene should be increased/decreased most of the time and the chemical does it.
- Gene should be increased/decreased most of the time but the chemical does the opposite.