46 Corticosteroid-binding globulin deficiency is a genetic disorder characterized by extreme tiredness (fatigue), particularly after physical exertion, and low blood pressure (hypotension). corticosteroid-binding globulin (cbg) is a protein primarily produced in the liver that attaches to cortisol, a hormone with numerous functions, including maintaining blood sugar levels, protecting the body from stress, and suppressing inflammation. when cortisol is needed in the body, cbg delivers the cortisol where it is needed and releases it.
signs and symptoms of cbg deficiency vary. while some individuals may experience no symptoms, others are found to have a fatty liver and chronic pain. some people with cbg deficiency also have chronic fatigue syndrome. cgb deficiency is caused by mutationsin the serpina6 gene. the serpina6 gene is commonly also referred to as the cbg gene. both autosomal dominantand autosomal recessiveinheritance have been reported. while there is still no cure, treatment options will depend on the type and severity of symptoms present and may involve several specialists
Disease Interacts with Genes
Disease Interacts with Substances
Processes Associated With Trait
Molecular Function Associated With Trait
Biological Processes Associated With Trait
Symptoms Associated With Trait
Selected genes are highlighted in orange, bookmarked
genes are green
- Chemical increases gene,
- Chemical decreases gene,
- Chemical increases and decreases gene simultaneosly,
No arrows - gene doesn't interact with the chemical.
- Gene should be increased/decreased most of the time and the chemical does it.
- Gene should be increased/decreased most of the time but the chemical does the opposite.