Cayler Cardiofacial Syndrome, also known as congenital unilateral hypoplasia of depressor anguli oris,is related to velocardiofacial syndrome and situs inversus,and has symptoms including skeletal muscle atrophy, cryptorchidism and polycystic kidney dysplasia. An important gene associated with Cayler Cardiofacial Syndrome is ACF (Asymmetric Crying Facies (Cayler Cardiofacial Syndrome)). Affiliated tissues include thymus, bone and kidney