Terminal Osseous Dysplasia, also known as terminal osseous dysplasia and pigmentary defects,is related to dwarfism and vesiculobullous skin disease,and has symptoms including mesomelic leg shortening, mesomelic arm shortening and abnormality of oral frenula. An important gene associated with Terminal Osseous Dysplasia is FLNA (Filamin A). Affiliated tissues include skin, bone and myeloid