Definition
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Description
Vinblastine is only found in individuals that have used or taken this drug. It is an antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)The antitumor activity of vinblastine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinblastine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic. Metabolism of vinblastine has been shown to be mediated by hepatic cytochrome P450 3A isoenzymes. Route of Elimination: The major route of excretion may be through the biliary system. Half Life: Triphasic: 35 min, 53 min, and 19 hours
- Uses/Sources: For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: Oral, mouse: LD<sub>50</sub> = 423 mg/kg; Oral, rat: LD<sub>50</sub> = 305 mg/kg.
Mechanism of Action
| Target Name | Mechanism of Action | References |
|---|---|---|
|
Tubulin beta chain Tubulin gamma-1 chain Tubulin alpha-1A chain Tubulin delta chain Tubulin epsilon chain Transcription factor AP-1 |
17126817 16111654 18220533 1818332 9664292 14619954 12907245 15579115 15498923 16555127 |