Definition
Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.
Description
Trimipramine is only found in individuals that have used or taken this drug. It is a tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. [PubChem]Trimipramine's mechanism of action differs from other tricyclic antidepressants. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).
Top Gene Interactions
General Information
- Metabolism: Hepatic Half Life: 11-18 hrs
- Uses/Sources: For the treatment of depression and depression accompanied by anxiety, agitation or sleep disturbance
- Symptoms: Side effects include agitation, coma, confusion, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high fever, irregular heart rate, low body temperature, muscle rigidity, overactive reflexes, severely low blood pressure, stupor, vomiting
- Treatment: Obtain an ECG and immediately initiate cardiac monitoring. Protect the patient's airway, establish an intravenous line and initiate gastric decontamination. A minimum of six hours of observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is necessary. If signs of toxicity occur at any time during this period, extended monitoring is required. (L1712)
- Route of Exposure: Oral. Rapid absorption
Mechanism of Action
| Target Name | Mechanism of Action | References |
|---|---|---|
|
5-hydroxytryptamine receptor 2A 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine receptor 1A Alpha-1A adrenergic receptor Alpha-2A adrenergic receptor Sodium-dependent dopamine transporter D(2) dopamine receptor 5-hydroxytryptamine receptor 1D Histamine H1 receptor Alpha-1B adrenergic receptor 5-hydroxytryptamine receptor 3A Alpha-2B adrenergic receptor D(1) dopamine receptor Beta adrenergic receptor Muscarinic acetylcholine receptor |
8863001 1979173 9537821 |
|
|
Sodium-dependent serotonin transporter Sodium-dependent noradrenaline transporter |
Trimipramine's mechanism of action differs from other tricyclic antidepressants. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). |
17016423 16388933 17139284 |
Trimipramine Interacts with Diseases
| Disease | Inference Score | References/Inference Genes |
| Poisoning | 3.7 |
|
| Kidney disease | 3.37 |
|