Definition
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
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ABCG2 protein affects the export of Topotecan | R |
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[Amlodipine co-treated with Topotecan] results in increased activity of CASP3 protein | R |
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benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of BIRC5 protein] | R |
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FOS mutant form inhibits the reaction [Topotecan results in increased expression of TREX1 mRNA] | R |
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Topotecan results in increased phosphorylation of H2AFX protein | R |
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Topotecan results in decreased expression of EGFR mRNA | R |
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JUN mutant form inhibits the reaction [Topotecan results in increased expression of TREX1 mRNA] | R |
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BID protein affects the susceptibility to Topotecan | R |
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Topotecan inhibits the reaction [Cisplatin affects the localization of HIF1A protein] | R |
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APAF1 promotes the reaction [Topotecan results in increased degradation of BCL2L1 protein] | R |