- Metabolism: Orally administered tioconazole is extensively metabolized. The major metabolites are glucuronide conjugates.
- Uses/Sources: For the local treatment of vulvovaginal candidiasis (moniliasis).
- Symptoms: Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
- Route of Exposure: Systemic absorption following a single intravaginal application of tioconazole in nonpregnant patients is negligible.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Lanosterol 14-alpha demethylase
Steroid 17-alpha-hydroxylase/17,20 lyase