Definition
Description
Top Gene Interactions
Related Pathways
Succinic Acid Health Effects
General Information
- Metabolism: Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29)
- Health Effects: Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitis. Cobalt may also have mutagenic and carcinogenic effects. (L29, L30)
- Symptoms: Cobalt inhalation can cause asthma-like breathing problems. Skin contact is known to result in contact dermatitis, which is characterized by irritation and rashes. Ingesting large amounts of cobalt may cause nausea and vomiting. (L2090)
- Treatment: Treatment of cobalt poisoning is symptomatic. (L29)
- Route of Exposure: Inhalation (L29) ; oral (L29) ; dermal (L29)
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate-semialdehyde dehydrogenase, mitochondrial Lysine-specific demethylase 4A Egl nine homolog 2 Egl nine homolog 1 Egl nine homolog 3 Transmembrane prolyl 4-hydroxylase Prolyl 4-hydroxylase subunit alpha-1 Prolyl 4-hydroxylase subunit alpha-2 Solute carrier family 13 member 3 Solute carrier family 13 member 2 Solute carrier family 13 member 1 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial 17-beta-hydroxysteroid dehydrogenase type 6 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Gamma-butyrobetaine dioxygenase Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Aspartyl/asparaginyl beta-hydroxylase Prolyl 3-hydroxylase 1 Prolyl 3-hydroxylase 2 Prolyl 3-hydroxylase 3 Succinate receptor 1 Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial Trimethyllysine dioxygenase, mitochondrial Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial Mitochondrial dicarboxylate carrier Lysine-specific demethylase 4C Lysine-specific demethylase 4E N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase Methylcytosine dioxygenase TET2 Methylcytosine dioxygenase TET1 Lysine-specific demethylase PHF2 Lysine-specific demethylase 4D Lysine-specific demethylase 5C Lysine-specific demethylase 4B Histone lysine demethylase PHF8 |
17584458 18942826 15713802 16735460 16524379 17619587 16188913 11161786 15944208 10779596 10592235 16371358 17526543 16689938 17668387 17610258 15853764 11697047 16232921 23999438 16027120 16176879 15646028 17520677 16942602 16288654 20025281 16374125 17139284 10820142 17192395 16405730 16484232 11752352 12231007 12397032 15986240 15989954 17016423 16030212 15639001 16232421 15561973 15388917 17636259 |
Succinic Acid Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Cataract | 9.27 |
|
Craniofacial Abnormalities | 7.58 |
|
Insulin resistance | 7.41 |
|
De Sanctis-Cacchione syndrome | 7.13 |
|
Hyperplasia | 7.06 |
|
Cerebrooculofacioskeletal Syndrome 1 | 6.78 |
|
UV-SENSITIVE SYNDROME 1 | 6.78 |
|
Achondrogenesis type 2 | 6.75 |
|
Epiphyseal Dysplasia, Multiple, with Myopia and Conductive Deafness | 6.75 |
|
Kniest dysplasia | 6.75 |
|
Legg-Calve-Perthes Disease | 6.75 |
|
Osteoarthritis with Mild Chondrodysplasia | 6.75 |
|
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | 6.75 |
|
Spondyloepiphyseal dysplasia, congenita | 6.75 |
|
Stickler syndrome, type 1 | 6.75 |
|
Stickler Syndrome, Type I, Nonsyndromic Ocular | 6.75 |
|
Strudwick syndrome | 6.75 |
|
Arthrogryposis | 6.43 |
|
Hyaloideoretinal degeneration of Wagner | 6.4 |
|
Megaepiphyseal dwarfism | 6.4 |
|