Definition
An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
Description
An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
General Information
- Uses/Sources: For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD<sub>50</sub>=1250 mg/kg (Orally in rat); LD<sub>50</sub>=3 ml/kg (Skin in rat)
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Glucocorticoid receptor Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor gamma Nuclear receptor subfamily 1 group I member 2 Vitamin K-dependent protein C Vitamin K-dependent protein S Mu-type opioid receptor Delta-type opioid receptor D(1A) dopamine receptor Beta-1 adrenergic receptor Retinoic acid receptor gamma-2 Thromboxane A2 receptor Alpha-2C adrenergic receptor Dual specificity protein phosphatase 3 Beta-secretase 1 P2Y purinoceptor 1 Caspase-5 Macrophage colony-stimulating factor 1 receptor |
17016423 19442540 23611293 1344580 11752352 |