SAPONINS

Definition

A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.

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Disease	Inference Score	References/Inference Genes
Diabetes Mellitus, Experimental	91.5	References/Inference Genes References Inference genes 23090186 10900012 16959961 18266981 21414306 11696579 16123366 20388520 14871415 15490108 16380483 19804535 20654064 21340626 21963884 21757225 22138235 24513509 19478208 12967931 23458895 12193562 22933112 15855331 20709041 23792339 14514642 22191573 12123627 18375438 BAX BCL2 CASP3 CAT FAS HMOX1 IFNG IL1B IL6 MMP2 MMP9 MPO NOS2 NOS3 NQO1 PPARG PTGS2 RELA SIRT1 SOD2 SREBF1 TNF
Reperfusion Injury	62.56	References/Inference Genes References Inference genes 15449323 17906103 10383581 15829914 16386242 21968084 7922267 24011919 23061969 17032661 17112405 8869312 21940958 10594344 11567657 8215636 23743330 10706834 18258783 16682413 17660127 25780291 12352873 12024109 18460982 20302854 19193722 23075401 19917352 19673871 24433871 12468449 20863214 10588920 16971220 19058328 16982915 23875703 BCL2 CASP3 CAT FOS GPT HMOX1 IL1B IL6 MMP9 MPO NOS2 NOS3 PPARG PTGS2 RELA SOD2 TNF
Brain Ischemia	60.72	References/Inference Genes References Inference genes 9236716 11756504 9778187 15829914 15737438 19429140 17564305 17901229 19417757 15060315 15756928 17394460 18628779 CASP3 CASP9 CAT IL18 IL1B IL6 MAPK1 MAPK3 MMP9 MPO NFKBIA NOS2 PTGS2 RELA SOD2 TNF
Breast carcinoma	60.33	References/Inference Genes References Inference genes 16954440 25322848 16870006 17965603 18509974 18398872 18507500 18511948 17516992 12517783 22572619 19756960 23621182 19617202 16127422 18498876 19435922 20154269 19446661 17285134 19671875 16298037 15631943 19385967 19839049 20228224 12432273 15375496 20562527 AKT1 BAX BCL2 CAT FOS HMOX1 IFNG IL1B IL6 MMP2 MMP9 NFKBIA NOS2 NOS3 NQO1 PTGS2 RAF1 RELA SIRT1 SOD2 TNF
Alcoholic liver cirrhosis	49.42	References/Inference Genes References Inference genes 20843640 19731237 23274713 BCL2 CAT CYP2E1 IL6 MMP2 MPO RELA SOD2 TNF
Lung Neoplasms	48.36	References/Inference Genes References Inference genes 12376484 22369883 14587096 11884234 12111688 18508827 12460898 16289808 21911043 12511591 26372664 7614408 17093202 22072123 22619562 1673675 18625569 26192916 15688187 12083368 18298334 AKT1 CYP1A2 CYP2E1 FAS FOS HMOX1 IFNG IL1B IL2 IL6 MAPK1 MAPK3 MPO NOS2 RAF1 TNF
Diabetes Mellitus, Type 2	46.99	References/Inference Genes References Inference genes 16249460 23500658 16959961 15592662 21484566 23834033 15531508 15111504 24513509 16123366 12136229 22244987 12716763 17317762 BCL2 CASP3 CAT CYP1A2 FAS HMOX1 IL6 NOS2 NOS3 PPARG RELA SIRT1 SOD2 TNF
Prostatic Neoplasms	45.44	References/Inference Genes References Inference genes 12429631 17609663 16458450 21716162 10753955 18829485 25970160 19240160 16606632 23315858 23441843 20124447 17507624 12771559 24763052 15126378 17646272 22564066 17199135 17688413 16506214 12445681 25246272 17196171 19011039 16733517 14754878 17115417 17542986 19074884 21062352 12592389 15672864 17465268 15682402 AKT1 BAX BCL2 CASP9 CYP2E1 HMOX1 IL18 IL2 IL6 MAPK3 MMP9 MPO NFE2L2 NOS3 NQO1 PTGS2 SIRT1 SOD2
Liver Cirrhosis, Experimental	44.06	References/Inference Genes References Inference genes 25380136 17565644 26435214 18380797 15095483 16025519 16610050 15996030 17072980 16085334 21163135 23341968 16953842 17347453 26806094 12389079 18555214 CYP1A2 FOS GPT HMOX1 IFNG IL18 IL1B MMP2 MMP9 NFE2L2 NFKBIA NOS2 NOS3 PTGS2 RELA SIRT1 SREBF1 TNF
Myocardial infarction	42.02	References/Inference Genes References Inference genes 21600015 11743230 20079142 24358288 16310260 12160945 10090345 25450231 15883752 19027736 16337503 10510054 11489778 BAX BCL2 CASP3 CAT HSPA5 IL1B IL6 MMP2 MMP9 NOS2 NOS3 SOD2 TNF
Hepatocellular carcinoma	41.58	References/Inference Genes References Inference genes 12024111 9029167 19731237 21147110 15162526 17510421 20084675 21472284 16767786 22022477 27022031 14563831 17615358 18760346 20818158 16374840 22561517 11872629 CYP2E1 FOS HSPA5 IL6 MMP2 MMP9 MPO NFE2L2 NFKBIA PPARG PTGS2 SOD2 SREBF1 TNF
Obesity	41.0	References/Inference Genes References Inference genes 23954404 26655953 10900012 17405841 9502777 11328671 21156398 23956348 19171794 11089532 20141834 18334666 16317704 24042701 24184811 18375438 AKT1 CYP2E1 HMOX1 HSPA5 IL6 MMP9 NQO1 PPARG PTGS2 SIRT1 SOD2 SREBF1 TNF
Radiation Injuries, Experimental	38.52	References/Inference Genes References Inference genes 20726721 22247605 11121210 IFNG IL18 IL1B MAPK1 MAPK3 SOD2 TNF
Colitis	37.23	References/Inference Genes References Inference genes 8698225 21444764 24782617 23810507 19940103 22410118 16365149 11820457 24548422 17449036 HMOX1 IFNG IL1B IL6 MPO NOS2 PTGS2 RELA SIRT1 TNF
Hypertension	37.08	References/Inference Genes References Inference genes 16959961 19008412 22352330 15199296 22228705 16331104 19018797 19407804 21051829 27292124 10075388 22349312 12044476 11566895 25101153 11457755 15834289 12947532 21593737 19666838 24039778 11834524 20667508 18605955 14757778 18836702 11479740 BCL2 CAT DRD2 FOS HMOX1 IL1B IL6 MMP2 MMP9 NOS2 NOS3 PPARG PTGS2 RELA SOD2 TNF
Heart failure	35.51	References/Inference Genes References Inference genes 19168511 18034274 17337591 21195081 3091246 22352330 16360360 20304815 15135663 26670611 21284947 20938210 16155095 24535859 16105639 15231041 CAT HMOX1 IFNG IL1B IL6 NOS2 NOS3 PPARG PTGS2 SIRT1 SOD2 TNF
Colonic neoplasm	35.34	References/Inference Genes References Inference genes 25279216 16105666 20715105 20540935 15059925 12842827 16086867 15725655 19147571 12189188 19028472 21081470 17667525 18987561 10223192 10866311 17404573 BAX BCL2 IFNG IL1B KCNH2 MMP9 NOS2 PPARG PTGS2 RELA SOD2 TNF
Neoplasm Metastasis	33.52	References/Inference Genes References Inference genes 21942447 22580338 16489006 17105418 12538496 18930813 21209944 15659795 19487542 8032535 21937440 22321834 23707804 12748951 18509974 23518002 18398872 16475674 23431386 CAT IL18 IL2 IL6 MAPK1 MAPK3 MMP2 MMP9 PTGS2 SOD2 TNF
Alzheimer's Disease	32.77	References/Inference Genes References Inference genes 19374891 18077176 15023809 16813604 10514107 11144356 16407166 15993441 17192785 18675847 BAX BCL2 CASP3 HMOX1 IL1B MPO NOS3 PPARG SOD2 TNF
Cardiomyopathies	31.86	References/Inference Genes References Inference genes 17943461 23536361 11978490 10620750 11800590 10716473 24448315 10920071 7979221 AKT1 CAT FAS IL1B IL6 MAPK1 MAPK3 PTGS2 SOD2 TNF

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Saponins

Definition

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Saponins Health Effects

Saponins Interacts with Diseases

Saponins Interacts with Genes

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