SAPONINS

Definition

A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.

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Disease	Inference Score	References/Inference Genes
Diabetes Mellitus, Experimental	91.5	References/Inference Genes References Inference genes 18375438 15490108 22191573 21963884 22933112 20709041 18266981 23458895 14514642 21340626 22138235 12123627 12193562 24513509 21414306 16380483 23090186 19478208 12967931 20654064 10900012 11696579 14871415 19804535 21757225 15855331 23792339 16123366 16959961 20388520 BAX BCL2 CASP3 CAT FAS HMOX1 IFNG IL1B IL6 MMP2 MMP9 MPO NOS2 NOS3 NQO1 PPARG PTGS2 RELA SIRT1 SOD2 SREBF1 TNF
Reperfusion Injury	62.56	References/Inference Genes References Inference genes 8869312 8215636 10706834 17906103 24011919 10594344 16682413 23075401 17032661 25780291 16971220 23061969 21968084 17660127 23875703 10383581 16982915 20302854 19193722 19917352 12024109 16386242 7922267 18460982 24433871 11567657 17112405 12352873 19058328 12468449 23743330 15449323 20863214 15829914 21940958 10588920 19673871 18258783 BCL2 CASP3 CAT FOS GPT HMOX1 IL1B IL6 MMP9 MPO NOS2 NOS3 PPARG PTGS2 RELA SOD2 TNF
Brain Ischemia	60.72	References/Inference Genes References Inference genes 15060315 19429140 18628779 15756928 9778187 9236716 17564305 15829914 17394460 11756504 17901229 19417757 15737438 CASP3 CASP9 CAT IL18 IL1B IL6 MAPK1 MAPK3 MMP9 MPO NFKBIA NOS2 PTGS2 RELA SOD2 TNF
Breast carcinoma	60.33	References/Inference Genes References Inference genes 19617202 19385967 18498876 20154269 16870006 12517783 15375496 17516992 18509974 15631943 20228224 18511948 19435922 16298037 23621182 17285134 20562527 19756960 18507500 17965603 16954440 16127422 22572619 25322848 19839049 19446661 12432273 18398872 19671875 AKT1 BAX BCL2 CAT FOS HMOX1 IFNG IL1B IL6 MMP2 MMP9 NFKBIA NOS2 NOS3 NQO1 PTGS2 RAF1 RELA SIRT1 SOD2 TNF
Alcoholic liver cirrhosis	49.42	References/Inference Genes References Inference genes 23274713 20843640 19731237 BCL2 CAT CYP2E1 IL6 MMP2 MPO RELA SOD2 TNF
Lung Neoplasms	48.36	References/Inference Genes References Inference genes 22072123 17093202 14587096 7614408 26192916 12376484 12460898 26372664 18298334 12111688 22369883 18625569 16289808 1673675 21911043 11884234 15688187 18508827 22619562 12511591 12083368 AKT1 CYP1A2 CYP2E1 FAS FOS HMOX1 IFNG IL1B IL2 IL6 MAPK1 MAPK3 MPO NOS2 RAF1 TNF
Diabetes Mellitus, Type 2	46.99	References/Inference Genes References Inference genes 16249460 12716763 22244987 15592662 15531508 23834033 16123366 17317762 21484566 12136229 23500658 16959961 15111504 24513509 BCL2 CASP3 CAT CYP1A2 FAS HMOX1 IL6 NOS2 NOS3 PPARG RELA SIRT1 SOD2 TNF
Prostatic Neoplasms	45.44	References/Inference Genes References Inference genes 17507624 17199135 21062352 12771559 25246272 19240160 17196171 15126378 17115417 16606632 19074884 10753955 15682402 23441843 12445681 12429631 16458450 17688413 15672864 25970160 20124447 18829485 23315858 24763052 17542986 17465268 17609663 22564066 16733517 16506214 12592389 21716162 19011039 14754878 17646272 AKT1 BAX BCL2 CASP9 CYP2E1 HMOX1 IL18 IL2 IL6 MAPK3 MMP9 MPO NFE2L2 NOS3 NQO1 PTGS2 SIRT1 SOD2
Liver Cirrhosis, Experimental	44.06	References/Inference Genes References Inference genes 18380797 17565644 23341968 16610050 15996030 26435214 17347453 12389079 16953842 25380136 17072980 18555214 16085334 21163135 15095483 16025519 26806094 CYP1A2 FOS GPT HMOX1 IFNG IL18 IL1B MMP2 MMP9 NFE2L2 NFKBIA NOS2 NOS3 PTGS2 RELA SIRT1 SREBF1 TNF
Myocardial infarction	42.02	References/Inference Genes References Inference genes 11743230 25450231 11489778 10510054 16337503 19027736 21600015 12160945 20079142 24358288 16310260 10090345 15883752 BAX BCL2 CASP3 CAT HSPA5 IL1B IL6 MMP2 MMP9 NOS2 NOS3 SOD2 TNF
Hepatocellular carcinoma	41.58	References/Inference Genes References Inference genes 9029167 20084675 17615358 22561517 16374840 11872629 14563831 27022031 22022477 16767786 18760346 19731237 15162526 21147110 21472284 12024111 17510421 20818158 CYP2E1 FOS HSPA5 IL6 MMP2 MMP9 MPO NFE2L2 NFKBIA PPARG PTGS2 SOD2 SREBF1 TNF
Obesity	41.0	References/Inference Genes References Inference genes 17405841 10900012 23954404 18375438 11089532 11328671 19171794 21156398 26655953 16317704 24042701 24184811 20141834 18334666 9502777 23956348 AKT1 CYP2E1 HMOX1 HSPA5 IL6 MMP9 NQO1 PPARG PTGS2 SIRT1 SOD2 SREBF1 TNF
Radiation Injuries, Experimental	38.52	References/Inference Genes References Inference genes 11121210 22247605 20726721 IFNG IL18 IL1B MAPK1 MAPK3 SOD2 TNF
Colitis	37.23	References/Inference Genes References Inference genes 17449036 11820457 19940103 24548422 24782617 22410118 16365149 23810507 21444764 8698225 HMOX1 IFNG IL1B IL6 MPO NOS2 PTGS2 RELA SIRT1 TNF
Hypertension	37.08	References/Inference Genes References Inference genes 24039778 11457755 21593737 18605955 12044476 11834524 10075388 22228705 19018797 25101153 19666838 19008412 22352330 20667508 11566895 19407804 15199296 15834289 11479740 22349312 18836702 14757778 21051829 16959961 16331104 27292124 12947532 BCL2 CAT DRD2 FOS HMOX1 IL1B IL6 MMP2 MMP9 NOS2 NOS3 PPARG PTGS2 RELA SOD2 TNF
Heart failure	35.51	References/Inference Genes References Inference genes 3091246 16105639 20304815 17337591 15231041 18034274 26670611 22352330 16155095 21195081 16360360 19168511 24535859 15135663 21284947 20938210 CAT HMOX1 IFNG IL1B IL6 NOS2 NOS3 PPARG PTGS2 SIRT1 SOD2 TNF
Colonic neoplasm	35.34	References/Inference Genes References Inference genes 19147571 15059925 16105666 12842827 17404573 15725655 21081470 17667525 20715105 16086867 25279216 10223192 10866311 19028472 20540935 12189188 18987561 BAX BCL2 IFNG IL1B KCNH2 MMP9 NOS2 PPARG PTGS2 RELA SOD2 TNF
Neoplasm Metastasis	33.52	References/Inference Genes References Inference genes 23431386 17105418 23707804 18930813 12748951 16489006 21209944 21942447 21937440 19487542 12538496 15659795 16475674 22321834 18509974 23518002 22580338 8032535 18398872 CAT IL18 IL2 IL6 MAPK1 MAPK3 MMP2 MMP9 PTGS2 SOD2 TNF
Alzheimer's Disease	32.77	References/Inference Genes References Inference genes 15993441 18675847 16407166 18077176 15023809 16813604 11144356 19374891 10514107 17192785 BAX BCL2 CASP3 HMOX1 IL1B MPO NOS3 PPARG SOD2 TNF
Cardiomyopathies	31.86	References/Inference Genes References Inference genes 10620750 10716473 10920071 24448315 7979221 11800590 11978490 17943461 23536361 AKT1 CAT FAS IL1B IL6 MAPK1 MAPK3 PTGS2 SOD2 TNF

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Saponins

Definition

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Saponins Health Effects

Saponins Interacts with Diseases

Saponins Interacts with Genes

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