Definition
Description
Top Gene Interactions
Related Pathways
General Information
- Uses/Sources: Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
- Health Effects: Investigated as a mutagen and reproductive effector.
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Androgen receptor Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Aldo-keto reductase family 1 member C1 |
15840771 15070163 16368818 23611293 14746879 18045204 11752352 5284360 15106733 15871445 15035793 15348270 15199473 |