Top Gene Interactions
- Uses/Sources: Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
- Health Effects: Investigated as a mutagen and reproductive effector.
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Prostaglandin G/H synthase 1
Prostaglandin G/H synthase 2
Aldo-keto reductase family 1 member C1