Description
Rifapentine is only found in individuals that have used or taken this drug. It is an antibiotic drug used in the treatment of tuberculosis. Rifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifapentine inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis. Rifapentine acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic Route of Elimination: Following a single 600 mg oral dose of radiolabeled rifapentine to healthy volunteers (n=4), 87% of the total 14C rifapentine was recovered in the urine (17%) and feces (70%).
- Uses/Sources: For the treatment of pulmonary tuberculosis.
- Route of Exposure: Rapidly and well absorbed from the gastrointestinal tract.
Rifapentine Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Prostatic Intraepithelial Neoplasia | 12.31 |
|
Astrocytoma | 11.43 |
|
Prostatic Neoplasms | 10.52 |
|
Infertility, Female | 10.32 |
|
Breast carcinoma | 10.05 |
|
Colorectal cancer | 8.04 |
|
CHOLESTASIS, BENIGN RECURRENT INTRAHEPATIC, 2 | 6.95 |
|
Androgen-Insensitivity Syndrome | 6.6 |
|
Bulbospinal neuronopathy, X-linked recessive | 6.6 |
|
Cholestasis, progressive familial intrahepatic 1 | 6.26 |
|
Hypospadias 1, X-Linked | 6.25 |
|
Afibrinogenemia | 6.15 |
|
Lithiasis | 6.01 |
|
Breast Neoplasms, Male | 5.7 |
|
Prostatic Neoplasms, Castration-Resistant | 5.18 |
|
Gestational diabetes | 5.01 |
|
Genital Diseases, Male | 4.82 |
|
Medulloblastoma | 4.69 |
|
Neoplasm Recurrence, Local | 4.69 |
|
Cholestasis, Intrahepatic | 4.58 |
|