RIBOFLAVIN

Definition

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE. Colour additive in food, nutrient supplement. Vitamin cofactor. Riboflavin, also known as vitamin B2 or additive E101, is an easily absorbed micronutrient with a key role in maintaining health in humans and animals. It is the central component of the cofactors FAD and FMN, and is therefore required by all flavoproteins. As such, vitamin B2 is required for a wide variety of cellular processes. It plays a key role in energy metabolism, and for the metabolism of fats, ketone bodies, carbohydrates, and proteins. (Wikipedia)

Description

Riboflavin is Found in These Foods

Top Gene Interactions

Related Pathways

Riboflavin Health Effects

General Information

Metabolism: Hepatic. Half Life: 66-84 minutes
Uses/Sources: For the treatment of ariboflavinosis (vitamin B2 deficiency).
Route of Exposure: Vitamin B2 is readily absorbed from the upper gastrointestinal tract.

Mechanism of Action

Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.

Target Name	Mechanism of Action	References
Androgen receptor Retinoic acid receptor alpha Flavin reductase (NADPH) Riboflavin kinase		16081269 15668000 14769034 16183635 16962092 23611293 16544142 21308351 17290783

Riboflavin Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Brain Ischemia	50.59	References/Inference Genes References Inference genes 17901229 17564305 15737438 17394460 19417757 9236716 15756928 17640816 11756504 15829914 9778187 14753426 15060315 19095966 15534175 CASP3 CASP9 CEBPB F2 IL10RB IL1B IL6 JUN MMP9 MTHFR NOS2 PARP1 PTGS2 TNF TP53
Diabetes Mellitus, Experimental	43.15	References/Inference Genes References Inference genes 23792339 14514642 22138235 12193562 20363216 16959961 16380483 19478208 14563825 21414306 21963884 20654064 16123366 12123627 23090186 20388520 22191573 24513509 BAX BCL2 CASP3 CPT1A IL1B IL6 MMP9 NOS2 PCK1 PPARGC1A PTGS2 TNF TP53
Breast carcinoma	42.24	References/Inference Genes References Inference genes 15631943 18509974 20228224 20941507 19617202 19435922 16968874 16818634 17293864 17388661 17450141 17516992 16870006 25330770 26229107 16777985 18498876 16244791 22572619 12165863 15601643 17285134 16298037 12517783 26192916 16127422 17595805 16954440 15802278 16322251 23621182 25151356 19446661 AKT1 BAX BCL2 BIRC5 CASP8 CPT1A CTNNB1 CXCL8 EDNRB IL1B IL6 JUN MMP9 MTHFR NOS2 PARP1 PTGS2 TNF TP53
Hepatocellular carcinoma	39.8	References/Inference Genes References Inference genes 15565109 20214788 12029619 2821104 18477611 20514400 17191126 17615358 12024111 17510421 21147764 16374840 16086872 19363144 25822088 27022031 20818158 22675488 14563831 20118494 8033108 12432545 9029167 11872629 20084675 BIRC5 CASP8 CEBPB CRP CTNNB1 CXCL8 F2 IL6 JUN MMP9 MYC PCK1 PTGS2 TNF TP53
Prostatic Neoplasms	35.99	References/Inference Genes References Inference genes 19240160 10753955 16606632 21946351 20875869 17199135 17363566 15126378 17196171 16733517 14754878 25970160 17542986 17609663 15682402 19011039 16421604 17173048 25246272 16506214 17967524 17606477 17202838 25735316 15672864 17566973 15342424 17804715 23704919 26005866 16434975 AKT1 BAX BCL2 CASP9 CTNNB1 CXCL8 GPX3 GSK3B HSP90B1 IL6 MMP9 MTHFR MYC PARP1 PTGS2 TP53
Reperfusion Injury	35.74	References/Inference Genes References Inference genes 7922267 23875703 11567657 19058328 19673871 12024109 15449323 10594344 12865660 17112405 15829914 10706834 10588920 18258783 25780291 12468449 23075401 10383581 21940958 18460982 23743330 16971220 16386242 17032661 23061969 BCL2 CASP3 CASP8 CXCL8 IL1B IL6 JUN MMP9 NOS2 PTGS2 SOCS1 TNF
Lung Neoplasms	35.56	References/Inference Genes References Inference genes 16108013 22619562 11798837 17114654 17450141 20716630 12460898 23692979 19180532 12511591 16289808 17389614 21552421 22369883 15981204 17325666 20727180 14587096 26372664 18372914 26192916 16410370 21911043 AKT1 BIRC5 CASP8 COL6A1 CRP CTNNB1 GPX3 IL1B IL6 JUN MTHFR MYC NOS2 TNF TP53
Colonic neoplasm	34.83	References/Inference Genes References Inference genes 16105666 12189186 14507667 10223192 18283038 17192441 17667525 15459021 17404573 12189188 18987561 12800193 21081470 15725655 15059925 19147571 19028472 12628520 16284371 17075118 16224667 9515794 26192916 12842827 22323126 BAX BCL2 BIRC5 CTNNB1 IL1B JUN MMP9 MTHFR MYC NOS2 PTGS2 TNF TP53
Obesity	32.82	References/Inference Genes References Inference genes 22841818 24042701 20882379 23954404 20561897 20141834 19270708 21156398 9502777 11328671 AKT1 CRP F2 GPX3 IL6 MMP9 PARP1 PCK1 PTGS2 SUCLG2 TNF
Stomach Neoplasms	30.92	References/Inference Genes References Inference genes 21173787 21364753 22385256 24816253 19584167 17003101 15492468 17450141 21347786 15993841 18505952 17171786 17355264 15723263 23593346 22414649 22484628 15201584 10404093 1733439 17224647 BIRC5 CASP8 CXCL8 IL1B IL6 JUN MTHFR MYC NDUFS1 PTGS2 TNF TP53
Adenocarcinoma	28.58	References/Inference Genes References Inference genes 10965019 22484628 18307536 14507667 26432044 10797276 1733439 21552421 19028472 15459021 21472143 11798837 10485483 16820089 BCL2 BIRC5 CASP8 CTNNB1 CXCL8 GPX3 IL1B MYC PTGS2 TNF TP53
Brain Injuries	28.57	References/Inference Genes References Inference genes 24675465 23159883 17640816 20810888 19800810 12410334 21549006 19631748 CEBPB GSK3B IL1B IL1R1 IL6 JUN MMP9 PARP1 PTGS2 TNF
Myocardial infarction	26.98	References/Inference Genes References Inference genes 9292507 15883752 22503866 19027736 16310260 25450231 9531249 16716347 20079142 11743230 11489778 24358288 10027711 10090345 BAX BCL2 CASP3 F2 GSK3B IL1B IL6 MMP9 NOS2 PPARGC1A TNF
Rheumatoid arthritis	26.23	References/Inference Genes References Inference genes 17379860 2001072 8391952 20008919 22104130 19192274 22446963 11978490 1568518 22450443 26001728 12566094 CRP CXCL8 F2 IL1B IL6 MTHFR PTGS2 PTPN2 RUNX2 TNF
Colorectal cancer	24.1	References/Inference Genes References Inference genes 20065508 17047490 17087956 21946351 12907644 23431386 21291235 12837940 11375891 10485483 12645814 25280562 16985020 17450141 17245555 19671906 16110022 15814641 10965019 17350979 20427397 16364925 17949449 18949393 16512993 16524972 15172127 18676755 15753380 15608557 AKT1 BCL2 BIRC5 CASP8 CTNNB1 CXCL8 MTHFR PTGS2 TNF TP53
Diabetes Mellitus, Type 2	23.42	References/Inference Genes References Inference genes 17317762 16387788 15531508 15592662 16123366 16959961 24513509 BCL2 CASP3 CASP8 CPT1A EDNRB IL6 NOS2 PPARGC1A TNF
Burns	22.27	References/Inference Genes References Inference genes 15650120 10431976 18277951 IL1B IL6 NOS2 PTGS2 TNF
Alzheimer's Disease	21.95	References/Inference Genes References Inference genes 17409235 8333868 18675847 22944069 18077176 17192785 BAX BCL2 CASP3 F2 GSK3B IL1B MTHFR TNF
Squamous cell carcinoma	21.15	References/Inference Genes References Inference genes 15956251 24224046 17979968 26372664 26432044 18202791 16543248 18572023 21351258 AKT1 BIRC5 CXCL8 IL6 MMP9 MYC PTGS2 TP53
Chronic lymphocytic leukemia	20.51	References/Inference Genes References Inference genes 16706930 18006695 23770605 21750559 16439677 16270354 16314473 BCL2 IL6 MTHFR PTGS2 TNFSF11 TP53

Definition

Description

Riboflavin is Found in These Foods

Top Gene Interactions

Related Pathways

Riboflavin Health Effects

General Information

Mechanism of Action

Riboflavin Interacts with Diseases

Riboflavin Interacts with Genes

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Riboflavin

Definition

Description

Riboflavin is Found in These Foods

Top Gene Interactions

Related Pathways

Riboflavin Health Effects

General Information

Mechanism of Action

Riboflavin Interacts with Diseases

Riboflavin Interacts with Genes

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