Top Gene Interactions
- Metabolism: Reboxetine is metabolized by dealkylation, hydroxylation and oxidation followed by glucuronide or sulphate conjugation. It is metabolized by the cytochrome P450 CYP isoenzyme 3A4. Half Life: 12.5 hours
- Uses/Sources: For the treatment of clinical depression.
- Symptoms: Reports of seizures (rare) have been reported
- Route of Exposure: Reboxetine is rapidly and extensively absorbed following oral administration.
Mechanism of Action
|Target Name||Mechanism of Action||References|
|Sodium-dependent noradrenaline transporter||Reboxetine is a selective inhibitor of noradrenaline reuptake. It inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine. Reboxetine does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.||