Definition
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Top Gene Interactions
Related Pathways
Quinidine Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Lipidoses | 23.84 |
References/Inference Genes
|
Diabetes Mellitus, Experimental | 22.35 | |
Liver Cirrhosis, Experimental | 20.68 | |
Breast carcinoma | 17.81 | |
Prostatic Neoplasms | 17.71 |
References/Inference Genes
|
Lung Neoplasms | 15.01 | |
Osteosarcoma | 13.91 | |
Drug-induced liver injury | 13.1 | |
Carcinoma, Non-Small-Cell Lung | 12.15 | |
Colonic neoplasm | 11.52 | |
Drug-Related Side Effects and Adverse Reactions | 11.36 | |
Colorectal cancer | 11.31 | |
Alcoholic liver cirrhosis | 10.91 |
|
Parkinson's disease | 10.78 | |
Diabetes Mellitus, Type 2 | 10.65 | |
Liver Neoplasms, Experimental | 10.65 | |
Disease Progression | 10.24 | |
Afibrinogenemia | 10.03 |
|
Urinary Bladder Neoplasms | 9.69 | |
Hyperoxia | 9.6 |
|