Definition
A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. Isol. from many plants, esp. fruits, such as Helichrysum, Euphorbia and Karwinskia spp. Present in the Solanaceae, Rhamnaceae, Passifloraceae and many other families. For example detected in almost all studied Umbelliferae. Nutriceutical with antiinflammatory props. and a positive influence on the blood lipid profile. Found in a wide variety of foodstuffs esp. apples, bee pollen, blackcurrants, capers, cocoa, cranberries, dock leaves, elderberries, fennel, lovage, red onions, ancho peppers, dill weed and tarragon
Description
Quercetin is a flavonoid widely distributed in many plants and fruits including red grapes, citrus fruit, tomato, broccoli and other leafy green vegetables, and a number of berries, including raspberries and cranberries. Quercetin itself (aglycone quercetin), as opposed to quercetin glycosides, is not a normal dietary component. Quercitin glycosides are converted to phenolic acids as they pass through the gastrointestinal tract. Quercetin has neither been confirmed scientifically as a specific therapeutic for any condition nor been approved by any regulatory agency. The U.S. Food and Drug Administration has not approved any health claims for quercetin. Nevertheless, the interest in dietary flavonoids has grown after the publication of several epidemiological studies showing an inverse correlation between dietary consumption of flavonols and flavones and reduced incidence and mortality from cardiovascular disease and cancer. In recent years, a large amount of experimental and some clinical data have accumulated regarding the effects of flavonoids on the endothelium under physiological and pathological conditions. The meta-analysis of seven prospective cohort studies concluded that the individuals in the top third of dietary flavonol intake are associated with a reduced risk of mortality from coronary heart disease as compared with those in the bottom third, after adjustment for known risk factors and other dietary components. A limited number of intervention studies with flavonoids and flavonoid containing foods and extracts has been performed in several pathological conditions. (A7896)
Quercetin is Found in These Foods
Top Gene Interactions
Related Pathways
Quercetin Health Effects
- 11beta-hydroxysteroid-dehydrogenase inhibitor
- 5-lipoxygenase inhibitor
- Aldehyde-oxidase inhibitor
- Allergenic
- Analgesic
- Anti aflatoxin
- Anti aging
- Anti allergic
- Anti Alzheimeran
- Anti anaphylactic
- Anti angiogenic
- Anti arthritic
- Anti asthmatic
- Anti atherosclerotic
- Anti carcinomic
- Anti cariogenic
- Anti cataract
- Anti colitic
- Anti complementary
- Anti Crohn's
- Anti cystitic
- Anti depressant
- Anti dermatitic
- Anti diabetic
- Anti elastase
- Anti encephalitic
- Anti escherichic
- Anti estrogenic
- Anti feedant
- Anti fibrosarcomic
- Anti flu
- Anti glucose-tolerance-factor
- Anti hepatotoxic
- Anti herpetic
- Anti histaminic
- Anti HIV
- Anti hydrophobic
- Anti hypertensive
- Anti inflammatory
- Anti leishmanic
- Anti leukemic
- Anti leukotriene
- Anti lipoperoxidant
- Anti malarial
- Anti melanomic
- Anti metastatic
- Anti myocarditic
- Anti nitrosaminic
- Anti nociceptive
- Antioxidant
- Anti pancreatitic
- Anti periodontal
- Anti peristaltic
- Anti permeability
- Anti peroxidant
- Anti pharyngitic
- Anti plaque
- Anti plasmodial
- Anti premenstrual syndrome
- Anti podriac
- Anti polio
- Anti proliferant
- Anti prostanoid
- Anti prostatitic
- Anti psoriac
- Anti radicular
- Anti spasmodic
- Anti streptococcic
- Anti thrombic
- Antitumor
- Anti ulcer
- Anti viral
- ATPase inhibitor
- Bacteristat
- Bradycardiac
- Calmodulin antagonist
- Cancer preventive
- Candidicide
- Carcinogenic
- Catabolic
- Catechol O-methyltransferase inhibitor
- Copper chelator
- Cyclooxygenase-2 inhibitor
- Cyclooxygenase inhibitor
- Cytochrome-P450-1A2 inhibitor
- Cytochrome-P450 inhibitor
- Cytotoxic
- Deiodinase inhibitor
- Diaphoretic
- Differentiator
- Fungicide
- Glucosyl-transferase inhibitor
- Hemostat
- Hepatomagenic
- Hepatoprotective
- HIV-reverse-transcriptase inhibitor
- Hypoglycemic
- INOS inhibitor
- Insulinogenic
- Juvabional
- Larvistat
- Lipoxygenase inhibitor
- Monoamine-oxidase-A inhibitor
- Metalloproteinase inhibitor
- Matrix-metalloproteinase-9 inhibitor
- NADPH-oxidase inhibitor
- Neutral-endopeptidase inhibitor
- Neuroprotective
- NF-kappa-B inhibitor
- Nitric-oxide inhibitor
- Nitric-oxide-synthase inhibitor
- Ornithine-decarboxylase inhibitor
- Pesticide
- Prostaglandin-E2 inhibitor
- Phospholipase inhibitor
- Protein kinase C inhibitor
- Plasmodicide
- Proliferant
- Prostaglandin synthesis inhibitor
- Protein kinase inhibitor
- Protein-tyrosine-kinase inhibitor
- Quinone-reductase inducer
- Teratologic
- TNF-alpha inhibitor
- Topoisomerase-II inhibitor
- Topoisomerase-I inhibitor
- Tumorigenic
- Tyrosinase inhibitor
- Tyrosine-kinase inhibitor
- Vasodilator
- VEGF inhibitor
- Aldose reductase inhibitor
- Allelochemic
- Anti aggregant
- Anti bacterial
- Xanthine oxidase inhibitor
- Anti gastric
- Anti gonadotropic
- Anti mutagenic
- Anti thiamin
- Anti trypanosomic
- Antitumor promoter
- Apoptotic
- CAMP-phosphodiesterase inhibitor
- Capillariprotective
- Cytochrome-p450 inducer
- Estrogenic
- Inotropic
- Mast-cell stabilizer
- Mutagenic
General Information
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Estrogen receptor beta Adenosine receptor A2a ATP synthase subunit beta, mitochondrial ATP synthase subunit alpha, mitochondrial Glycogen synthase kinase-3 beta ATP synthase subunit gamma, mitochondrial Tyrosine-protein kinase HCK Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform UDP-glucuronosyltransferase 3A1 Serine/threonine-protein kinase pim-1 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Serine/threonine-protein kinase 17B |
23611293 10592235 17139284 17016423 |