Definition
One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Description
One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic Half Life: 96 hours
- Uses/Sources: For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
- Route of Exposure: Well absorbed with peak levels occurring between 2 to 6 hours following administration
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Androgen receptor Cellular tumor antigen p53 Retinoic acid receptor alpha Alpha-2A adrenergic receptor Sodium-dependent dopamine transporter Sodium-dependent noradrenaline transporter 5-hydroxytryptamine receptor 7 D(1A) dopamine receptor Dihydrofolate reductase Nuclear factor erythroid 2-related factor 2 |
9380737 23611293 11752352 12951104 9108546 |
Pyrimethamine Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Myocardial Reperfusion Injury | 19.15 |
|
Reperfusion Injury | 17.65 |
|
Turner Syndrome | 17.55 |
|
Breast carcinoma | 17.54 |
|
Marfan Syndrome | 15.59 |
|
Brain Ischemia | 14.86 |
|
Ureteral Calculi | 14.2 |
|
Diabetes Mellitus, Type 2 | 13.44 |
|
Status Epilepticus | 13.41 |
|
Asthma | 13.26 |
|
Hepatitis, Chronic | 11.82 |
|
Nervous System Diseases | 11.72 |
|
Dermatitis, Contact | 11.67 |
|
Kidney stone | 11.44 |
|
Protein Deficiency | 10.91 |
|
Myocardial infarction | 10.48 |
|
Diabetes Mellitus, Experimental | 10.43 |
|
Asphyxia Neonatorum | 10.4 |
|
Schistosomiasis mansoni | 9.86 |
|
Mycoplasma Infections | 9.83 |
|