Definition
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Description
Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. Pyridoxine is one of the compounds that can be called vitamin B6. Pyridoxine assists in the balancing of sodium and potassium as well as promoting red blood cell production. It is linked to cancer immunity and helps fight the formation of homocysteine. It has been suggested that Pyridoxine might help children with learning difficulties, and may also prevent dandruff, eczema, and psoriasis. In addition, pyridoxine can help balance hormonal changes in women and aid in immune system. Lack of pyridoxine may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth. Deficiency, though rare because of widespread distribution in foods, leads to the development of peripheral neuritis in adults and affects the central nervous system in children.
Top Gene Interactions
Pyridoxine Health Effects
- Analgesic
- Anti acne
- Anti anemic
- Anti asthmatic
- Anti atherosclerotic
- Anti autistic
- Anti cheilitic
- Anti depressant
- Anti dermatitic
- Anti diabetic
- Antidote
- Anti dyskinetic
- Anti emetic
- Anti epileptic
- Anti glossitic
- Anti infertility
- Anti lithic
- Anti morning sickness
- Anti monosodium-glutamate-sensitivity
- Anti nephritic
- Anti neuritic
- Anti neuropathic
- Anti oxaluric
- Anti Parkinsonian
- Anti premenstrual syndrome
- Anti schizophrenic
- Anti sickling
- Anti spasmodic
- Anti TMJ
- Anti ulcer
- Anti vertigo
- Dopaminergic
- Neurotoxic
- Progesteronigenic
- Anti aggregant
- Anti carpal-tunnel
- Anti homocystinuric
- Anti hyperkinetic
- Anti hyperventilation
- Anti prolactin
- Anti radiation
- Anti seborrheic
General Information
- Metabolism: Hepatic. Half Life: 15-20 days
- Uses/Sources: For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
- Symptoms: Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
- Treatment: Administer charcoal as a slurry. (T273)
- Route of Exposure: Oral; parenteral (intramuscular). The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD50: 4 gm/kg (oral, rat)
Mechanism of Action
| Target Name | Mechanism of Action | References |
|---|---|---|
|
Serum albumin Pyridoxal phosphate phosphatase Pyridoxal kinase Cystathionine beta-synthase Phosphoserine aminotransferase Alpha-aminoadipic semialdehyde dehydrogenase |
Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA). |
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Pyridoxine Interacts with Diseases
| Disease | Inference Score | References/Inference Genes |
| Hyperostosis | 6.0 |
|
| Bone Diseases, Endocrine | 5.65 |
|
| Hypoparathyroidism familial isolated | 5.65 |
|
| Muscular Dystrophy, Animal | 5.2 |
|
| Rickets | 5.07 |
|
| Fractures, Bone | 5.0 |
|
| Hyperphosphatemia | 4.93 |
|
| Hyperparathyroidism, Secondary | 4.88 |
|
| Bowen's Disease | 4.85 |
|
| Osteoporosis, Postmenopausal | 4.72 |
|
| Ceroid lipofuscinosis, neuronal 1, infantile | 4.65 |
|
| Hypercalciuria | 4.64 |
|
| Bone Resorption | 4.45 |
|
| Heart failure | 4.45 |
|
| Uremia | 4.3 |
|
| Hypocalcemia | 4.28 |
|
| Lymphoma, Non-Hodgkin | 4.15 |
|
| Hypercalcemia | 4.06 |
|
| Osteoporosis | 3.94 |
|
| Nervous System Diseases | 3.76 |
|