Definition
Description
Putrescine is Found in These Foods
Top Gene Interactions
Related Pathways
Putrescine Health Effects
General Information
- Metabolism: Uremic toxins tend to accumulate in the blood either through dietary excess or through poor filtration by the kidneys. Most uremic toxins are metabolic waste products and are normally excreted in the urine or feces.
- Uses/Sources: Naturally produced by the body (endogenous).
- Health Effects: Chronic exposure to uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease.
- Symptoms: As a uremic toxin, this compound can cause uremic syndrome. Uremic syndrome may affect any part of the body and can cause nausea, vomiting, loss of appetite, and weight loss. It can also cause changes in mental status, such as confusion, reduced awareness, agitation, psychosis, seizures, and coma. Abnormal bleeding, such as bleeding spontaneously or profusely from a very minor injury can also occur. Heart problems, such as an irregular heartbeat, inflammation in the sac that surrounds the heart (pericarditis), and increased pressure on the heart can be seen in patients with uremic syndrome. Shortness of breath from fluid buildup in the space between the lungs and the chest wall (pleural effusion) can also be present.
- Treatment: Kidney dialysis is usually needed to relieve the symptoms of uremic syndrome until normal kidney function can be restored.
- Route of Exposure: Endogenous, Ingestion, Dermal (contact)
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Beta-1 adrenergic receptor Beta-2 adrenergic receptor Solute carrier family 22 member 8 Ornithine decarboxylase S-adenosylmethionine decarboxylase proenzyme Klotho NADPH oxidase 4 |
25041433 17016423 22419041 17139284 20885010 10592235 |
Putrescine Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Myocardial Reperfusion Injury | 14.88 |
|
Hypertension | 14.07 |
|
Reperfusion Injury | 13.86 |
|
Status Epilepticus | 13.43 |
|
Colonic neoplasm | 12.46 |
|
Nervous System Diseases | 12.05 |
|
Esophageal Neoplasms | 11.22 |
|
Mycoplasma Infections | 11.19 |
|
Retinal Detachment | 10.41 |
|
Brain Ischemia | 10.26 |
|
Diabetes Mellitus, Experimental | 9.64 |
|
Asthma | 9.45 |
|
Diabetes Mellitus, Type 2 | 9.44 |
|
Prostatic Neoplasms | 9.32 |
|
Cell Transformation, Neoplastic | 9.18 |
|
Amyotrophic lateral sclerosis 1 | 8.78 |
|
Autism | 8.73 |
|
Breast carcinoma | 8.69 |
|
Subarachnoid Hemorrhage | 8.29 |
|
Stomach Neoplasms | 8.19 |
|