PROBENECID

Definition

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.

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Probenecid Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Colorectal cancer	35.85	References/Inference Genes References Inference genes 24836286 21544799 16293616 23431386 22294766 18949393 20065508 16879199 22180778 ABCA8 ABCC1 ABCC2 ABCC4 ABCC5 ABCC6 ABCG2 BCL2 CXCL8 NR4A2 TGFB1 TLR4 TNF
Rheumatoid arthritis	21.43	References/Inference Genes References Inference genes 12566094 2001072 22450443 23897011 17379860 8391952 19192274 ABCC2 ABCC4 ABCC5 ABCG2 CAT CXCL8 SLC22A4 TNF
Diabetes Mellitus, Experimental	19.41	References/Inference Genes References Inference genes 19478208 22138235 15855331 20709041 24513509 12193562 18829990 11812764 16959961 23090186 17177138 12967931 12123627 20388520 BAX BCL2 CAT CYBA REN TGFB1 TNF
Nervous System Diseases	18.92	References/Inference Genes References Inference genes 11150333 10773198 21064136 14999072 9427479 12890883 21245421 23452774 9634552 ABCC2 ABCG2 CASP9 CYP2C8 GFAP SLC2A1 SLC6A3 TNF
Alcoholic liver cirrhosis	16.78	References/Inference Genes References Inference genes 23274713 BCL2 CAT TGFB1 TNF
Reperfusion Injury	16.52	References/Inference Genes References Inference genes 12865660 17112405 19058328 15449323 16971220 16682413 8215636 23875703 15829914 12024109 23743330 12468449 18460982 10706834 25780291 27064547 BCL2 CAT CCL2 CXCL8 IL1A TLR4 TNF
Kidney Failure, Chronic	16.03	References/Inference Genes References Inference genes 19539174 16518626 19420110 CAT CCL2 CYBA NOX4 TGFB1 TNF
Diabetes Mellitus, Type 2	15.73	References/Inference Genes References Inference genes 24513509 16959961 23500658 15531508 9589670 15111504 BCL2 CAT CYBA SLC2A1 TGFB1 TNF
Colonic neoplasm	14.03	References/Inference Genes References Inference genes 12842827 15090606 16670197 20715105 10223192 17404573 19028472 11953883 19147571 15059925 BAX BCL2 NOX4 SLC22A1 SLC2A1 SLC5A8 TNF
Breast carcinoma	13.58	References/Inference Genes References Inference genes 23621182 12517783 10930538 17516992 22572619 25078270 19446661 16954440 25322848 15496535 20197467 16298037 ABCC1 ABCG2 BAX BCL2 CAT CXCL8 CYP3A4 SLC2A1 TNF
Mesothelioma, Malignant	13.56	References/Inference Genes References Inference genes 25756049 16850164 25162674 22784439 BCL2 CXCL8 IL1A SLC22A5 SLC2A1
Liver Cirrhosis, Experimental	12.72	References/Inference Genes References Inference genes 12586293 26806094 15772939 16085334 15492853 16579972 25380136 ABCC2 ABCC5 CCL2 CYBA NOX4 SLC22A8 TGFB1 TLR4 TNF
Hypertension	12.51	References/Inference Genes References Inference genes 17324946 45830 22228705 1071603 18679781 7721401 20667508 21593737 998518 6381767 17537837 11682445 1149188 17272743 18605955 27292124 20505675 10075388 18847324 62162 19770776 20429690 19018797 16685210 12600921 20811386 21393355 12414515 11479740 11501062 ABCC1 BCL2 CAT CCL2 CYBA REN TGFB1 TLR4 TNF UMOD
Pulmonary Fibrosis	12.18	References/Inference Genes References Inference genes 24762191 17266442 19817698 17720292 11394717 16324872 15286001 19684199 26163174 26817844 25216247 17894541 16365456 26368622 CAT CCL2 CXCL8 TGFB1 TNF
Cell Transformation, Neoplastic	12.12	References/Inference Genes References Inference genes 2848196 23518002 21742780 22015448 2543982 22666341 20172950 25448439 11953883 20516118 BCL2 CAT CXCL8 SLC2A1 TGFB1
Myocardial Reperfusion Injury	11.79	References/Inference Genes References Inference genes 20026869 14998631 12087064 21600015 BAX CASP9 CAT CCL2
Osteoporosis, Postmenopausal	11.51	References/Inference Genes References Inference genes 17227729 9032749 10750555 CAT TGFB1 TNF
Psoriatic arthritis	11.51	References/Inference Genes References Inference genes 12746914 19732956 CXCL8 NR4A2 TNF
Brain Ischemia	11.41	References/Inference Genes References Inference genes 11756504 15829914 17564305 15756928 17394460 CASP9 CAT CCL2 IL1A TNF
Renal hypouricemia	11.35	References/Inference Genes References Inference genes 18989453 14655203 14694169 22132990 SLC22A12 SLC2A9

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Probenecid Interacts with Diseases

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Probenecid

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Probenecid Interacts with Diseases

Probenecid Interacts with Genes

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