PROBENECID

Definition

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.

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Probenecid Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Colorectal cancer	35.85	References/Inference Genes References Inference genes 16879199 22180778 22294766 16293616 21544799 24836286 18949393 20065508 23431386 ABCA8 ABCC1 ABCC2 ABCC4 ABCC5 ABCC6 ABCG2 BCL2 CXCL8 NR4A2 TGFB1 TLR4 TNF
Rheumatoid arthritis	21.43	References/Inference Genes References Inference genes 8391952 12566094 2001072 23897011 19192274 17379860 22450443 ABCC2 ABCC4 ABCC5 ABCG2 CAT CXCL8 SLC22A4 TNF
Diabetes Mellitus, Experimental	19.41	References/Inference Genes References Inference genes 12193562 19478208 18829990 16959961 12123627 11812764 20388520 12967931 17177138 20709041 22138235 24513509 15855331 23090186 BAX BCL2 CAT CYBA REN TGFB1 TNF
Nervous System Diseases	18.92	References/Inference Genes References Inference genes 12890883 10773198 9634552 9427479 23452774 11150333 21064136 21245421 14999072 ABCC2 ABCG2 CASP9 CYP2C8 GFAP SLC2A1 SLC6A3 TNF
Alcoholic liver cirrhosis	16.78	References/Inference Genes References Inference genes 23274713 BCL2 CAT TGFB1 TNF
Reperfusion Injury	16.52	References/Inference Genes References Inference genes 16971220 16682413 19058328 23743330 10706834 17112405 8215636 15449323 12024109 18460982 25780291 12865660 12468449 23875703 15829914 27064547 BCL2 CAT CCL2 CXCL8 IL1A TLR4 TNF
Kidney Failure, Chronic	16.03	References/Inference Genes References Inference genes 19420110 16518626 19539174 CAT CCL2 CYBA NOX4 TGFB1 TNF
Diabetes Mellitus, Type 2	15.73	References/Inference Genes References Inference genes 15531508 16959961 9589670 15111504 24513509 23500658 BCL2 CAT CYBA SLC2A1 TGFB1 TNF
Colonic neoplasm	14.03	References/Inference Genes References Inference genes 19028472 15090606 16670197 11953883 12842827 10223192 19147571 15059925 17404573 20715105 BAX BCL2 NOX4 SLC22A1 SLC2A1 SLC5A8 TNF
Breast carcinoma	13.58	References/Inference Genes References Inference genes 16298037 10930538 16954440 25322848 17516992 23621182 15496535 12517783 22572619 20197467 19446661 25078270 ABCC1 ABCG2 BAX BCL2 CAT CXCL8 CYP3A4 SLC2A1 TNF
Mesothelioma, Malignant	13.56	References/Inference Genes References Inference genes 22784439 16850164 25756049 25162674 BCL2 CXCL8 IL1A SLC22A5 SLC2A1
Liver Cirrhosis, Experimental	12.72	References/Inference Genes References Inference genes 15492853 16579972 26806094 16085334 12586293 15772939 25380136 ABCC2 ABCC5 CCL2 CYBA NOX4 SLC22A8 TGFB1 TLR4 TNF
Hypertension	12.51	References/Inference Genes References Inference genes 12600921 1071603 16685210 20505675 18847324 11682445 21593737 11501062 21393355 998518 20667508 1149188 27292124 11479740 19018797 17537837 17272743 12414515 18679781 20429690 17324946 19770776 22228705 45830 6381767 62162 20811386 10075388 7721401 18605955 ABCC1 BCL2 CAT CCL2 CYBA REN TGFB1 TLR4 TNF UMOD
Pulmonary Fibrosis	12.18	References/Inference Genes References Inference genes 17266442 15286001 11394717 25216247 24762191 26368622 26163174 19684199 19817698 16365456 16324872 26817844 17894541 17720292 CAT CCL2 CXCL8 TGFB1 TNF
Cell Transformation, Neoplastic	12.12	References/Inference Genes References Inference genes 23518002 2543982 11953883 20172950 20516118 22015448 25448439 2848196 21742780 22666341 BCL2 CAT CXCL8 SLC2A1 TGFB1
Myocardial Reperfusion Injury	11.79	References/Inference Genes References Inference genes 20026869 12087064 21600015 14998631 BAX CASP9 CAT CCL2
Osteoporosis, Postmenopausal	11.51	References/Inference Genes References Inference genes 17227729 10750555 9032749 CAT TGFB1 TNF
Psoriatic arthritis	11.51	References/Inference Genes References Inference genes 12746914 19732956 CXCL8 NR4A2 TNF
Brain Ischemia	11.41	References/Inference Genes References Inference genes 17394460 11756504 17564305 15829914 15756928 CASP9 CAT CCL2 IL1A TNF
Renal hypouricemia	11.35	References/Inference Genes References Inference genes 18989453 22132990 14694169 14655203 SLC22A12 SLC2A9

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Probenecid Interacts with Diseases

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Probenecid

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Probenecid Interacts with Diseases

Probenecid Interacts with Genes

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