PROBENECID

Definition

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.

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Probenecid Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Colorectal cancer	35.85	References/Inference Genes References Inference genes 18949393 21544799 22294766 24836286 23431386 22180778 16879199 20065508 16293616 ABCA8 ABCC1 ABCC2 ABCC4 ABCC5 ABCC6 ABCG2 BCL2 CXCL8 NR4A2 TGFB1 TLR4 TNF
Rheumatoid arthritis	21.43	References/Inference Genes References Inference genes 12566094 17379860 2001072 8391952 23897011 22450443 19192274 ABCC2 ABCC4 ABCC5 ABCG2 CAT CXCL8 SLC22A4 TNF
Diabetes Mellitus, Experimental	19.41	References/Inference Genes References Inference genes 24513509 19478208 20388520 12193562 23090186 11812764 20709041 16959961 18829990 22138235 15855331 17177138 12967931 12123627 BAX BCL2 CAT CYBA REN TGFB1 TNF
Nervous System Diseases	18.92	References/Inference Genes References Inference genes 10773198 9427479 21064136 12890883 11150333 21245421 23452774 14999072 9634552 ABCC2 ABCG2 CASP9 CYP2C8 GFAP SLC2A1 SLC6A3 TNF
Alcoholic liver cirrhosis	16.78	References/Inference Genes References Inference genes 23274713 BCL2 CAT TGFB1 TNF
Reperfusion Injury	16.52	References/Inference Genes References Inference genes 25780291 16971220 15829914 23743330 15449323 8215636 18460982 17112405 12024109 19058328 16682413 27064547 23875703 10706834 12468449 12865660 BCL2 CAT CCL2 CXCL8 IL1A TLR4 TNF
Kidney Failure, Chronic	16.03	References/Inference Genes References Inference genes 16518626 19420110 19539174 CAT CCL2 CYBA NOX4 TGFB1 TNF
Diabetes Mellitus, Type 2	15.73	References/Inference Genes References Inference genes 24513509 15111504 16959961 15531508 9589670 23500658 BCL2 CAT CYBA SLC2A1 TGFB1 TNF
Colonic neoplasm	14.03	References/Inference Genes References Inference genes 10223192 12842827 17404573 11953883 15090606 15059925 19028472 16670197 20715105 19147571 BAX BCL2 NOX4 SLC22A1 SLC2A1 SLC5A8 TNF
Breast carcinoma	13.58	References/Inference Genes References Inference genes 12517783 20197467 22572619 25078270 23621182 16298037 16954440 10930538 25322848 15496535 19446661 17516992 ABCC1 ABCG2 BAX BCL2 CAT CXCL8 CYP3A4 SLC2A1 TNF
Mesothelioma, Malignant	13.56	References/Inference Genes References Inference genes 22784439 16850164 25756049 25162674 BCL2 CXCL8 IL1A SLC22A5 SLC2A1
Liver Cirrhosis, Experimental	12.72	References/Inference Genes References Inference genes 16579972 12586293 15772939 16085334 26806094 15492853 25380136 ABCC2 ABCC5 CCL2 CYBA NOX4 SLC22A8 TGFB1 TLR4 TNF
Hypertension	12.51	References/Inference Genes References Inference genes 20505675 11479740 22228705 7721401 11501062 6381767 11682445 62162 1149188 21593737 17537837 18679781 19018797 20429690 18605955 16685210 1071603 17324946 12414515 19770776 18847324 10075388 20667508 27292124 20811386 998518 12600921 45830 21393355 17272743 ABCC1 BCL2 CAT CCL2 CYBA REN TGFB1 TLR4 TNF UMOD
Pulmonary Fibrosis	12.18	References/Inference Genes References Inference genes 26368622 17894541 25216247 16365456 17266442 19684199 11394717 15286001 26817844 17720292 26163174 24762191 19817698 16324872 CAT CCL2 CXCL8 TGFB1 TNF
Cell Transformation, Neoplastic	12.12	References/Inference Genes References Inference genes 21742780 20172950 11953883 20516118 2543982 22015448 2848196 22666341 23518002 25448439 BCL2 CAT CXCL8 SLC2A1 TGFB1
Myocardial Reperfusion Injury	11.79	References/Inference Genes References Inference genes 21600015 14998631 12087064 20026869 BAX CASP9 CAT CCL2
Osteoporosis, Postmenopausal	11.51	References/Inference Genes References Inference genes 9032749 10750555 17227729 CAT TGFB1 TNF
Psoriatic arthritis	11.51	References/Inference Genes References Inference genes 19732956 12746914 CXCL8 NR4A2 TNF
Brain Ischemia	11.41	References/Inference Genes References Inference genes 17394460 15829914 11756504 17564305 15756928 CASP9 CAT CCL2 IL1A TNF
Renal hypouricemia	11.35	References/Inference Genes References Inference genes 14694169 22132990 18989453 14655203 SLC22A12 SLC2A9

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Probenecid Interacts with Diseases

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Probenecid

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Probenecid Interacts with Diseases

Probenecid Interacts with Genes

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