Definition
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Top Gene Interactions
Related Pathways
Probenecid Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Colorectal cancer | 35.85 | |
Rheumatoid arthritis | 21.43 | |
Diabetes Mellitus, Experimental | 19.41 | |
Nervous System Diseases | 18.92 | |
Alcoholic liver cirrhosis | 16.78 |
|
Reperfusion Injury | 16.52 | |
Kidney Failure, Chronic | 16.03 | |
Diabetes Mellitus, Type 2 | 15.73 | |
Colonic neoplasm | 14.03 | |
Breast carcinoma | 13.58 | |
Mesothelioma, Malignant | 13.56 | |
Liver Cirrhosis, Experimental | 12.72 | |
Hypertension | 12.51 |
References/Inference Genes
|
Pulmonary Fibrosis | 12.18 | |
Cell Transformation, Neoplastic | 12.12 | |
Myocardial Reperfusion Injury | 11.79 |
References/Inference Genes
|
Osteoporosis, Postmenopausal | 11.51 |
|
Psoriatic arthritis | 11.51 |
|
Brain Ischemia | 11.41 | |
Renal hypouricemia | 11.35 |
References/Inference Genes
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