PROBENECID

Definition

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.

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Probenecid Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Colorectal cancer	35.85	References/Inference Genes References Inference genes 22294766 23431386 18949393 22180778 24836286 16879199 20065508 21544799 16293616 ABCA8 ABCC1 ABCC2 ABCC4 ABCC5 ABCC6 ABCG2 BCL2 CXCL8 NR4A2 TGFB1 TLR4 TNF
Rheumatoid arthritis	21.43	References/Inference Genes References Inference genes 8391952 22450443 12566094 23897011 19192274 17379860 2001072 ABCC2 ABCC4 ABCC5 ABCG2 CAT CXCL8 SLC22A4 TNF
Diabetes Mellitus, Experimental	19.41	References/Inference Genes References Inference genes 12123627 20388520 17177138 20709041 23090186 11812764 12967931 22138235 15855331 18829990 24513509 12193562 16959961 19478208 BAX BCL2 CAT CYBA REN TGFB1 TNF
Nervous System Diseases	18.92	References/Inference Genes References Inference genes 21245421 21064136 9427479 12890883 14999072 11150333 10773198 9634552 23452774 ABCC2 ABCG2 CASP9 CYP2C8 GFAP SLC2A1 SLC6A3 TNF
Alcoholic liver cirrhosis	16.78	References/Inference Genes References Inference genes 23274713 BCL2 CAT TGFB1 TNF
Reperfusion Injury	16.52	References/Inference Genes References Inference genes 25780291 12468449 15829914 18460982 16682413 16971220 19058328 23743330 15449323 12024109 17112405 12865660 10706834 8215636 27064547 23875703 BCL2 CAT CCL2 CXCL8 IL1A TLR4 TNF
Kidney Failure, Chronic	16.03	References/Inference Genes References Inference genes 19420110 16518626 19539174 CAT CCL2 CYBA NOX4 TGFB1 TNF
Diabetes Mellitus, Type 2	15.73	References/Inference Genes References Inference genes 15111504 23500658 9589670 15531508 24513509 16959961 BCL2 CAT CYBA SLC2A1 TGFB1 TNF
Colonic neoplasm	14.03	References/Inference Genes References Inference genes 16670197 20715105 12842827 19147571 10223192 19028472 15090606 17404573 15059925 11953883 BAX BCL2 NOX4 SLC22A1 SLC2A1 SLC5A8 TNF
Breast carcinoma	13.58	References/Inference Genes References Inference genes 23621182 16954440 12517783 17516992 19446661 25078270 25322848 15496535 20197467 16298037 22572619 10930538 ABCC1 ABCG2 BAX BCL2 CAT CXCL8 CYP3A4 SLC2A1 TNF
Mesothelioma, Malignant	13.56	References/Inference Genes References Inference genes 22784439 16850164 25756049 25162674 BCL2 CXCL8 IL1A SLC22A5 SLC2A1
Liver Cirrhosis, Experimental	12.72	References/Inference Genes References Inference genes 25380136 15492853 16579972 16085334 26806094 12586293 15772939 ABCC2 ABCC5 CCL2 CYBA NOX4 SLC22A8 TGFB1 TLR4 TNF
Hypertension	12.51	References/Inference Genes References Inference genes 18679781 27292124 22228705 17537837 20667508 18847324 20429690 11501062 18605955 11682445 998518 19770776 6381767 62162 21593737 17324946 1071603 11479740 20811386 45830 7721401 12414515 19018797 20505675 1149188 21393355 17272743 16685210 10075388 12600921 ABCC1 BCL2 CAT CCL2 CYBA REN TGFB1 TLR4 TNF UMOD
Pulmonary Fibrosis	12.18	References/Inference Genes References Inference genes 17720292 15286001 26163174 19817698 25216247 17266442 17894541 26817844 26368622 24762191 11394717 16365456 16324872 19684199 CAT CCL2 CXCL8 TGFB1 TNF
Cell Transformation, Neoplastic	12.12	References/Inference Genes References Inference genes 20516118 2848196 25448439 20172950 22015448 22666341 21742780 2543982 11953883 23518002 BCL2 CAT CXCL8 SLC2A1 TGFB1
Myocardial Reperfusion Injury	11.79	References/Inference Genes References Inference genes 20026869 12087064 14998631 21600015 BAX CASP9 CAT CCL2
Osteoporosis, Postmenopausal	11.51	References/Inference Genes References Inference genes 10750555 17227729 9032749 CAT TGFB1 TNF
Psoriatic arthritis	11.51	References/Inference Genes References Inference genes 19732956 12746914 CXCL8 NR4A2 TNF
Brain Ischemia	11.41	References/Inference Genes References Inference genes 17394460 15829914 11756504 15756928 17564305 CASP9 CAT CCL2 IL1A TNF
Renal hypouricemia	11.35	References/Inference Genes References Inference genes 14655203 22132990 18989453 14694169 SLC22A12 SLC2A9

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Probenecid Interacts with Diseases

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Probenecid

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Probenecid Interacts with Diseases

Probenecid Interacts with Genes

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