Definition
Description
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Prednisone is completely converted to the active metabolite prednisolone by 11‘_-hydroxysteroid dehydrogenases. It is then further metabolized mainly in the liver. The exposure of prednisolone is 4-6 fold higher than that of prednisone. Route of Elimination: Excreted in the urine as sulfate and glucuronide conjugates. Half Life: Half life of both the immediate- and delayed- release formulation is 2 to 3 hours.
- Uses/Sources: For the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison's disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis, Crohn's disease, acquired hemolytic anemia, congenital hypoplastic anemia, erythroblastopenia, adult secondary thrombocytopenia, adult idiopathic thrombocytopenia purpura, acute or subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute or chronic lymphocytic leukemia, Hodgkin's or non-Hodgkin's lynphomas, Waldenstrom's macroglobulinemia, primary brain tumors (adjunct), nephrotic syndrome, tuberculous meningitis, multiple sclerosis, myasthenia gravis. cerebral edema, chorioretinitis, diffuse posterior choroiditis, aleergic conjunctivitis, Herpes zoster ophthalmicus, anterior segment inflammation, iridocyclitis, iritis, keratitis, optoc neuritis, sympathetic ophthalmia, corneal marginal allergic ulcers, symptomatic sarcoidosis, Loeffler's syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy and aspiration pneumonitis.
- Route of Exposure: Readily absorbed from the gastrointestinal tract. Rayos, the delayed-release formulation, has a 4-hour release time. To compare, the delayed-release formulation has a Tmax of 6.0 - 6.5 hours in healthy male subjects, whereas the immediate-release formulation has a Tmax of 2.0 hours. The rate of absorption, Cmax, and exposure is comparable between formulations.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Glucocorticoid receptor Androgen receptor Nuclear receptor subfamily 1 group I member 2 Corticosteroid 11-beta-dehydrogenase isozyme 1 |
23611293 20634231 |
Prednisone Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Hepatitis, Autoimmune | 13.55 |
|
Asthma | 13.26 |
|
Pulmonary Fibrosis | 10.59 |
|
Mesothelioma, Malignant | 9.98 |
|
Hepatocellular carcinoma | 9.72 |
|
Arthritis, Experimental | 9.38 |
|
Pleural Diseases | 9.25 |
|
Radiation Injuries, Experimental | 9.19 |
|
Oral Submucous Fibrosis | 9.17 |
|
Pneumonia | 8.49 |
|
Sezary Syndrome | 8.33 |
|
Atopic eczema | 8.3 |
|
Adrenocortical Carcinoma | 8.0 |
|
Colonic neoplasm | 7.96 |
|
Lung Diseases | 7.88 |
|
Lung Neoplasms | 7.82 |
|
Allergy | 7.71 |
|
Brain Ischemia | 7.66 |
|
Leishmaniasis, Cutaneous | 7.66 |
|
Nephrotic syndrome | 7.58 |
|