Definition
Present in black pepper (Piper nigrum). Flavouring agent Piperidine (Azinane after the Hantzsch?Widman nomenclature) is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene units and one nitrogen atom. It is a colorless fuming liquid with an odor described as ammoniacal, pepper-like; the name comes from the genus name Piper, which is the Latin word for pepper. Piperidine is a widely used building block and chemical reagent in the synthesis of organic compounds, including pharmaceuticals.; Piperidine is a widely used secondary amine. It is widely used to convert ketones to enamines. Enamines derived from piperidine can be used in the Stork enamine alkylation reaction.; Piperidine is used as a solvent and as a base. The same is true for certain derivatives: N-formylpiperidine is a polar aprotic solvent with better hydrocarbon solubility than other amide solvents, and 2,2,6,6-tetramethylpiperidine is highly sterically hindered base, useful because of its low nucleophilicity and high solubility in organic solvents.
Top Gene Interactions
Related Pathways
Piperidine Health Effects
Piperidine Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Alzheimer's Disease | 22.88 |
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Prostatic Neoplasms | 20.7 |
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Breast carcinoma | 19.69 |
|
Diabetes Mellitus, Experimental | 16.67 |
|
Autism | 15.26 |
|
Nerve Degeneration | 14.43 |
|
Adenocarcinoma, Clear Cell | 14.07 |
|
Penile Neoplasms | 13.91 |
|
Lung Neoplasms | 13.7 |
|
Mesothelioma, Malignant | 13.58 |
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Entamoebiasis | 12.82 |
|
Muscular Dystrophies | 12.48 |
|
Renal cell carcinoma | 12.48 |
|
Aids | 11.64 |
|
Amyloidosis | 11.54 |
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Learning Disorders | 11.37 |
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Cell Transformation, Neoplastic | 11.27 |
|
Dermatitis, Allergic Contact | 11.23 |
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Liver Cirrhosis, Experimental | 11.23 |
|
Urinary Bladder Neoplasms | 11.18 |
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