Description
Phenacemide is only found in individuals that have used or taken this drug. It is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.Phenacemide binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronization. Hypersynchronization is what often causes seizures.
General Information
- Metabolism: Metabolized in the liver by hepatic microsomal enzymes, where it is inactivated by p-hydroxylation. Half Life: 22-25 hours.
- Uses/Sources: Used to control certain seizures in the treatment of epilepsy.
- Health Effects: May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease.
- Route of Exposure: Almost completely absorbed.
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD50: 987 mg/kg (Oral, Mouse) (A308) LD50: 2500 mg/kg (Oral, Rabbit) (A308) LD50: 1600 mg/kg (Oral, Rat) (A308)
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Sodium channel protein type 1 subunit alpha | Phenacemide binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronization. Hypersynchronization is what often causes seizures. |
17139284 17016423 |