Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Pentamidine is only found in individuals that have used or taken this drug. It is an antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. [PubChem] The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins.
Top Gene Interactions
- Metabolism: Hepatic. Half Life: 9.1-13.2 hours
- Uses/Sources: For the treatment of pneumonia due to Pneumocystis carinii.
- Symptoms: Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.
- Route of Exposure: Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Protein tyrosine phosphatase type IVA 3
Solute carrier family 22 member 1
Solute carrier family 22 member 2
Multidrug and toxin extrusion protein 1
Multidrug and toxin extrusion protein 2
Solute carrier family 22 member 3
Suppressor of tumorigenicity 14 protein
Pentamidine Interacts with Diseases
|Disease||Inference Score||References/Inference Genes|
|Leukemia-Lymphoma, Adult T-Cell||14.38||
|Neoplasm Recurrence, Local||10.15||
|Dermatitis, Allergic Contact||9.36||
|MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO||9.0||
|Diabetes Mellitus, Type 1||8.81||