Description
Oxiconazole is only found in individuals that have used or taken this drug. It is an antifungal medication typically administered in a cream or lotion to treat skin infections such as athlete's foot, jock itch and ringworm. Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Oxiconazole can increase membrane permeability to zinc, augmenting its cytotoxicity.
Top Gene Interactions
Related Pathways
General Information
- Uses/Sources: For treatment of dermal fungal infection.
- Symptoms: Side effects incliude pruritus, burning, irritation, erythema, stinging and allergic contact dermatitis and folliculitis, fissuring, maceration rash and nodules.
- Route of Exposure: Topical; systemic absorption of oxiconazole is low.
Mechanism of Action
| Target Name | Mechanism of Action | References |
|---|---|---|
| Ergosterol biosynthetic protein 28 | Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. |
17139284 17016423 |
Oxiconazole Interacts with Diseases
| Disease | Inference Score | References/Inference Genes |
| Osteosarcoma | 16.89 |
|
| Prostatic Neoplasms | 15.21 |
|
| Breast carcinoma | 14.55 |
|
| Infertility, Female | 10.38 |
|
| Esophageal Neoplasms | 9.41 |
|
| Endometriosis | 9.17 |
|
| Adenocarcinoma | 8.14 |
|
| Fatty Liver | 7.99 |
|
| Autism | 7.95 |
|
| Aromatase deficiency | 6.89 |
|
| Sexual Infantilism | 6.89 |
|
| Kidney disease | 6.67 |
|
| Critical Illness | 6.09 |
|
| Jaundice, Neonatal | 5.99 |
|
| Drug-induced liver injury | 5.71 |
|
| Hypopituitarism | 5.42 |
|
| Gestational diabetes | 5.3 |
|
| Barrett's esophagus | 5.19 |
|
| Carotid Artery Diseases | 5.18 |
|
| Ureteral Calculi | 5.18 |
|