Ornithine Health Effects
- Metabolism: Ornithine undergoes extensive metabolism in the liver to L-arginine, polyamines, and proline, and several other metabolites.
- Uses/Sources: Used for nutritional supplementation, also for treating dietary shortage or imbalance. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing.
- Health Effects: Chronically high levels of ornithine are associated with at least 9 inborn errors of metabolism including: Cystathionine Beta-Synthase Deficiency, Hyperornithinemia with gyrate atrophy, Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, Hyperprolinemia Type II, Lysinuric Protein Intolerance, Ornithine Aminotransferase Deficiency, Ornithine Transcarbamylase Deficiency and Prolinemia Type II.
- Route of Exposure: Absorbed from the small intestine via a sodium-dependent active transport process
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: Oral, rat LD<sub>50</sub> = 10000 mg/kg
Mechanism of Action
|Target Name||Mechanism of Action||References|
High affinity cationic amino acid transporter 1
Cationic amino acid transporter 4
Cationic amino acid transporter 3
Low affinity cationic amino acid transporter 2
Glycine amidinotransferase, mitochondrial
Ornithine carbamoyltransferase, mitochondrial
Ornithine aminotransferase, mitochondrial
Ornithine decarboxylase antizyme 1
Mitochondrial ornithine transporter 2
Mitochondrial ornithine transporter 1
Ornithine decarboxylase antizyme 2
Ornithine decarboxylase antizyme 3