Top Gene Interactions
- Metabolism: Primarily hepatic. In vitro, naratriptan is metabolized by a wide range of cytochrome P450 isoenzymes into a number of inactive metabolites. Half Life: 5-8 hours
- Uses/Sources: For the acute treatment of migraine attacks with or without aura in adults.
- Symptoms: Symptoms of overdose include light-headedness, loss of coordination, tension in the neck, and tiredness.
- Treatment: There is no specific antidote to naratriptan. Standard supportive treatment should be applied as required. If the patient presents with chest pain or other symptoms consistent with angina pectoris, ECG monitoring should be performed for evidence of ischemia. (L1712)
- Route of Exposure: Well absorbed (74% oral biovaility), absorption is rapid with peak plasma concentrations after 2-5 hours. The rate of absorption is slower during a migraine attack.
Mechanism of Action
|Target Name||Mechanism of Action||References|
|5-hydroxytryptamine receptor 1A||
5-hydroxytryptamine receptor 1B
5-hydroxytryptamine receptor 1D
5-hydroxytryptamine receptor 1F
|Naratriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blood vessel constriction.||