Definition
Constit. of dill, nutmeg, parsley and many other essential oils. May be responsible for psychotic effects of nutmeg at large doses Myristicin, 3-methoxy,4,5-methylendioxy-allylbenzene, is a natural organic compound present in the essential oil of nutmeg and to a lesser extent in other spices such as parsley and dill. Myristicin is a naturally occurring insecticide and acaricide with possible neurotoxic effects on dopaminergic neurons[citation needed]. It has hallucinogenic properties at doses much higher than used in cooking. Myristicin is a weak inhibitor of monoamine oxidase.
Description
Myristicin is found in anise. Myristicin is a constituent of dill, nutmeg, parsley and many other essential oils. May be responsible for psychotic effects of nutmeg at large doses Myristicin, 3-methoxy,4,5-methylendioxy-allylbenzene, is a natural organic compound present in the essential oil of nutmeg and to a lesser extent in other spices such as parsley and dill. Myristicin is a naturally occurring insecticide and acaricide with possible neurotoxic effects on dopaminergic neurons[citation needed]. It has hallucinogenic properties at doses much higher than used in cooking. Myristicin is a weak inhibitor of monoamine oxidase. Myristicin has been shown to exhibit apoptotic and hepatoprotective functions (A7836, A7837). Myristicin belongs to the family of Benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole.
Top Gene Interactions
Related Pathways
Myristicin Health Effects
- Amphetaminagenic
- Anesthetic
- Anti depressant
- Anti inflammatory
- Antioxidant
- Anti spasmodic
- Anti stress
- Calcium antagonist
- Cancer preventive
- Diuretic
- Flavor
- Fungicide
- Hallucinogenic
- Hepatotoxic
- Hypotensive
- Insecticide
- Larvicide
- Monoamine-oxidase inhibitor
- Neurotoxic
- Oxytocic
- Paralytic
- Pesticide
- Psychoactive
- Sedative
- Serotoninergic
- Tachycardic
- Utero tonic
- Anti aggregant
- Hypnotic
General Information
- Uses/Sources: Myristicin is a plant toxin found in the essential oil of nutmeg and to a lesser extent in other spices such as parsley and dill. It is a naturally occurring insecticide and acaricide. (L1271)
- Health Effects: Myristicin has neurotoxic effects and hallucinogenic properties. (L1271)
- Symptoms: Myristicin produces a semi-conscious state, and may also cause euphoria, bloodshot eyes, and memory disturbances. It is also known to induce psychoactive effects such as visual distortions. (L1271)
- Route of Exposure: Oral (ingestion) (L1817) ; dermal (L1817)
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD50: 3000 mg/kg (Oral, Mouse) (L1272) LD50: 340 mg/kg (Intraperitoneal, Mouse) (L1272) LD50: 5610 mg/kg (Dermal, Rat) (L1272) LD50: 1470 mg/kg (Subcutaneous, Mouse) (L1272) LD50: 8000 mg/kg (Intramuscular, Mouse) (L1272)
Myristicin Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Prostatic Neoplasms | 29.28 |
|
Breast carcinoma | 24.13 |
|
Genetic Predisposition to Disease | 19.35 |
|
Stomach Neoplasms | 17.28 |
|
Carcinoma, Adenoid Cystic | 14.12 |
|
Colorectal cancer | 12.43 |
|
Breast Neoplasms, Male | 11.68 |
|
Colorectal Neoplasms, Hereditary Nonpolyposis | 11.29 |
|
Squamous cell carcinoma | 11.09 |
|
Lung adenocarcinoma | 10.48 |
|
Esophageal Neoplasms | 9.49 |
|
Pancreatic carcinoma | 8.11 |
|
Head and Neck Neoplasms | 7.64 |
|
Occupational Diseases | 7.54 |
|
Diabetes Mellitus, Type 2 | 7.47 |
|
Urinary Bladder Neoplasms | 7.33 |
|
Spinal muscular atrophy with respiratory distress 1 | 7.05 |
|
Osteosarcoma | 6.97 |
|
Melanoma | 6.86 |
|
Colorectal Adenomatous Polyposis, Autosomal Recessive | 6.78 |
|