Top Gene Interactions
- Metabolism: Hepatic Half Life: 75 hours
- Uses/Sources: For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. Mitoxantrone is an Anthracenedione (not an anthracycline) antineoplastic agent.
- Health Effects: Cardiomyopathy is a particularly concerning effect as it is irreversible. [Wikipedia]
- Symptoms: Severe leukopenia with infection.
- Route of Exposure: Intravenous injection. Poorly absorbed following oral administration.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Multidrug resistance-associated protein 1
Cytochrome P450 2D6
Solute carrier family 22 member 1
Solute carrier family 22 member 2
Multidrug and toxin extrusion protein 1
Tyrosine-protein kinase BTK
Multidrug and toxin extrusion protein 2
Solute carrier family 22 member 3
P2Y purinoceptor 12
DNA topoisomerase 2-alpha
ATP-binding cassette sub-family G member 2
|Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.||