- Metabolism: Hepatic. Methyprylon is almost completely metabolized. Half Life: 6-16 hours
- Uses/Sources: For the treatment of insomnia.
- Health Effects: They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive.
- Symptoms: Symptoms of overdose include excitation and convulsions.
Mechanism of Action
|Target Name||Mechanism of Action||References|
|Gamma-aminobutyric acid receptor subunit alpha-1||Methyprylon binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.||
|GABA-A receptor (anion channel)||