- Metabolism: Half Life: 1.4-2.6 hours for mesuximide and 28-38 hours for the active metabolite.
- Uses/Sources: For the control of absence (petit mal) seizures that are refractory to other drugs.
- Health Effects: May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease.
- Symptoms: Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression. Levels greater than 40 µg/mL have caused toxicity and coma has been seen at levels of 150 µg/mL.
- Treatment: Treatment should include emesis (unless the patient is or could rapidly become obtunded, comatose, or convulsing) or gastric lavage, activated charcoal, cathartics, and general supportive measures. Charcoal hemoperfusion may be useful in removing the N-desmethyl metabolite of methsuximide. Forced diuresis and exchange transfusions are ineffective. (L1712)
- Route of Exposure: Oral
Mechanism of Action
|Target Name||Mechanism of Action||References|
|Voltage-dependent T-type calcium channel subunit alpha-1G||