Definition
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
Description
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic.
- Uses/Sources: For use in the induction and maintenance of general anesthesia
- Health Effects: Detrimental effects on the kidneys. [Wikipedia]
- Symptoms: Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.
- Route of Exposure: Oral
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD50: 3600 mg/kg (Oral, Rat) (A308)
Mechanism of Action
| Target Name | Mechanism of Action | References |
|---|---|---|
|
Transient receptor potential cation channel subfamily A member 1 GABA-A receptor (anion channel) |
21078588 |
|
|
Calcium-transporting ATPase type 2C member 1 Gamma-aminobutyric acid receptor subunit alpha-1 NADH-ubiquinone oxidoreductase chain 1 Glutamate receptor 1 Potassium voltage-gated channel subfamily A member 1 Glycine receptor subunit alpha-1 ATP synthase subunit delta, mitochondrial Cytochrome b5 |
Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor. |
17139284 2877820 6698981 17016423 2912373 16182240 2988561 |
Methoxyflurane Interacts with Diseases
| Disease | Inference Score | References/Inference Genes |
| Alcohol dependence | 10.78 |
|
| TOBACCO ADDICTION, SUSCEPTIBILITY TO | 9.75 |
|
| Hepatitis C | 7.33 |
|
| Autism | 6.77 |
|
| Coumarin Resistance | 5.37 |
|
| Opisthorchiasis | 5.17 |
|
| Carcinoma, Large Cell | 4.91 |
|
| Liver Diseases, Parasitic | 4.82 |
|
| Heroin Dependence | 4.8 |
|
| Gliosarcoma | 4.79 |
|
| Adenocarcinoma | 4.75 |
|
| Cocaine dependence | 4.72 |
|
| Pulmonary Emphysema | 4.65 |
|
| Carcinoma, Small Cell | 4.62 |
|
| Nasopharyngeal neoplasm | 4.62 |
|
| Prostatic Neoplasms | 4.54 |
|
| Nicotine dependence | 4.22 |
|
| Hepatic Encephalopathy | 4.15 |
|
| Respiratory Distress Syndrome, Adult | 4.11 |
|
| Alcoholic liver cirrhosis | 4.03 |
|