Top Gene Interactions
- Metabolism: Half Life: 24 to 48 hours
- Uses/Sources: Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.
- Symptoms: Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.
- Route of Exposure: Oral; Intramuscular injection. Well absorbed from the gastrointestinal tract.
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: Oral LD<sub>50</sub> is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Potassium voltage-gated channel subfamily H member 2
Muscarinic acetylcholine receptor M1
Muscarinic acetylcholine receptor M2
Muscarinic acetylcholine receptor M3
Muscarinic acetylcholine receptor M4
5-hydroxytryptamine receptor 2C
5-hydroxytryptamine receptor 1A
Alpha-2A adrenergic receptor
D(3) dopamine receptor
D(1A) dopamine receptor
Histamine H1 receptor
5-hydroxytryptamine receptor 6
5-hydroxytryptamine receptor 2A
D(2) dopamine receptor
|Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. In addition, the phenothiazines exhibit at least part of their activities through depression of hypothalamic centers. Neurochemically, the phenothiazines are thought to exert their effects by a central adrenergic blocking action.||