Definition
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)
Top Gene Interactions
Meprobamate Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Drug Metabolism, Poor, CYP2C19-Related | 6.23 | |
Primary ovarian insufficiency | 5.03 |
|
Kidney Failure, Chronic | 3.78 |
|
Thrombosis | 3.53 |
|
Cardiovascular disease | 3.47 |
|
Acute kidney injury | 3.17 |
|
Prostatic Neoplasms | 3.09 |
|
Drug-induced liver injury | 2.94 |
|