Definition

AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.

Description

Memantine is an amantadine derivative with low to moderate-affinity for NMDA receptors. It is a noncompetitive NMDA receptor antagonist that binds preferentially to NMDA receptor-operated cation channels. It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. It is under investigation for the treatment of Alzheimer's disease, but there has been no clinical support for the prevention or slowing of disease progression.

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General Information

Mechanism of Action

Memantine Interacts with Diseases

Memantine Interacts with Genes