MANEB

Definition

Manganese derivative of ethylenebisdithiocarbamate. It is used in agriculture as a fungicide and has been shown to cause irritation to the eyes, nose, skin, and throat. Fungicide esp. for protection of potatoes and tomatoes

Description

Maneb is a foliate fungicide and is a polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand to control a wide range of diseases including blight, leaf spot, rust, downy mildew and scab. Its mode of action is non-specific with protective action.

Top Gene Interactions

Related Pathways

Maneb Health Effects

Neurotoxic

General Information

Uses/Sources: This is a man-made compound that is used as a pesticide.

Mechanism of Action

Target Name	Mechanism of Action	References
Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Retinoic acid receptor alpha Receptor-type tyrosine-protein phosphatase beta Receptor-type tyrosine-protein phosphatase F Receptor-type tyrosine-protein phosphatase mu Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 13 Tyrosine-protein phosphatase non-receptor type 4 Tyrosine-protein phosphatase non-receptor type 9 Nuclear receptor subfamily 1 group I member 2 Mu-type opioid receptor Epidermal growth factor receptor Vascular endothelial growth factor receptor 3 RAC-alpha serine/threonine-protein kinase Casein kinase II subunit alpha Bile salt sulfotransferase Interleukin-1 alpha Cytochrome P450 2C19 Urokinase plasminogen activator surface receptor Nuclear receptor subfamily 1 group I member 3 Urokinase-type plasminogen activator Interstitial collagenase Nociceptin receptor Dual specificity protein phosphatase 3 Receptor-type tyrosine-protein phosphatase C P2Y purinoceptor 1 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Tyrosine-protein kinase ABL1 Low molecular weight phosphotyrosine protein phosphatase RAC-beta serine/threonine-protein kinase Aurora kinase A Vascular endothelial growth factor receptor 1 Tyrosine-protein kinase Fyn Glycogen synthase kinase-3 beta Insulin-like growth factor 1 receptor MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 5 Serine/threonine-protein kinase MARK1 Serine/threonine-protein kinase Nek2 Serine/threonine-protein kinase PAK 4 5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase Ribosomal protein S6 kinase alpha-5 Serine/threonine-protein kinase Sgk1 Proto-oncogene tyrosine-protein kinase Src Angiopoietin-1 receptor Tyrosine-protein kinase BTK Cyclin-dependent kinase 2 Dual specificity tyrosine-phosphorylation-regulated kinase 1B		23611293

Maneb Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Diabetes Mellitus, Experimental	67.34	References/Inference Genes References Inference genes 18375438 22191573 20709041 23458895 21505870 21340626 22138235 12123627 12193562 24513509 17177138 16380483 18603373 23090186 19478208 22342832 20654064 25808216 19804535 21757225 24632065 15855331 23792339 16123366 16959961 20388520 BAX BCL2 BCL2L1 CASP3 CAT CHRM2 CYP1A1 FAS GPX1 HK1 HMOX1 IFNG IGF1 IL1B IRS2 MFGE8 NEUROD1 NOS2 NQO1 PAX6 SERPINE1 SIRT1 SOD1 SOD2 TGFB1 TNF VEGFA
Breast carcinoma	60.12	References/Inference Genes References Inference genes 20135347 15601643 25267515 15665820 19617202 19385967 23063927 17293864 19655245 17595805 21036696 12517783 12810669 12839951 17516992 16583263 20228224 15631943 18511948 17450141 16298037 17634480 23621182 20562527 16792888 19756960 23839043 17520698 17965603 16954440 14975756 16777985 22572619 20941507 23535733 19636701 25322848 19839049 17255770 20948315 14672398 21127199 19446661 23180569 12432273 18398872 21466612 ACHE AKT1 BAX BCL2 BMP2 BMP4 CASP7 CASP8 CAT CCND1 CYP1A1 DAP3 DLL1 E2F1 ENO1 FOS GPX1 GPX4 GSTP1 HEY2 HEYL HMOX1 HSP90AA1 HSPA1B IFNG IGF1 IL1B KDR KIT MDM4 MFGE8 MTHFR NOS2 NQO1 NRG1 RAF1 SIRT1 SOD2 STAT3 TNF
Prostatic Neoplasms	50.13	References/Inference Genes References Inference genes 11196146 17148459 15159307 20356562 18082198 17199135 17507624 17967524 16427044 21062352 12771559 25246272 16606632 19074884 20052738 15682402 19223546 23441843 23704919 25970160 20124447 16931574 24586243 18829485 23315858 16465378 15302576 19593445 17013881 17542986 11275366 14975756 17465268 22581815 15598783 24763052 12893367 22564066 16733517 17606477 12592389 12727815 17919073 17173048 19208208 16421604 16908180 15538743 16172807 17646272 ACHE AKT1 BAD BAX BCL2 CASP9 CCND1 CDKN1A CLU CYP1A1 CYP2E1 GSK3B GSTP1 HMOX1 IGF1 ITPR1 LIFR MAPK3 MTHFR MYC NFE2L2 NQO1 PDHA1 PLAUR PRKCZ SERPINE1 SIRT1 SOD2 STAT3 TGFB1 VEGFA
Stomach Neoplasms	43.91	References/Inference Genes References Inference genes 19584167 16367923 18505952 1733439 21173787 22414649 26401016 23382965 21628965 15378696 21364753 17450141 14503839 19424620 21347786 15201584 17171786 15492468 20729852 17003101 21133646 22490514 14647439 16314833 10853026 25279216 BCL2L1 BDNF BMP2 CASP8 CCND1 CDKN1A ENO1 GSTP1 HMOX1 IL1B IRS2 MAPK1 MAPK3 MTHFR MYC PAX6 PDHA1 PLCE1 SERPINE1 SOD2 STAT3 TNF
Squamous cell carcinoma	40.76	References/Inference Genes References Inference genes 22072123 15557674 18572023 17566705 21401805 12543247 15274141 21472714 26432044 20852150 21351258 25199511 15956251 AKT1 CCL2 CCND1 CYP1A2 ENO1 GPX1 MAPK1 MAPK3 MYC NFE2L2 SIRT3 SOD2 STAT3 TGFB1 VEGFA
Diabetes Mellitus, Type 2	40.75	References/Inference Genes References Inference genes 22244987 23795780 15531508 15111504 16123366 12136229 17107852 23834033 23500658 16959961 24513509 BCL2 BCL2L1 CASP3 CASP8 CAT CYP1A2 FAS GPX1 HK1 HMOX1 IRS2 NEUROD1 NFKB1 NOS2 PAX6 SIRT1 SOD1 SOD2 TGFB1 TNF VEGFA
Lung Neoplasms	40.25	References/Inference Genes References Inference genes 22072123 17093202 14587096 7614408 26192916 12376484 12460898 17909032 22369883 11103801 25640678 17418594 17450141 16007126 16289808 1673675 21911043 19946270 11884234 17389614 11074608 11307925 15688187 18508827 12466968 22619562 22537621 11641043 12511591 12083368 AKT1 BCL2L1 CASP8 CCND1 CDKN1A CYP1A2 CYP2E1 FAS FOS GPX1 GSTP1 HMOX1 IFNG IL1B MAPK1 MAPK3 MTHFR MYC NOS2 PARK2 PRDX1 RAF1 TGFB1 TNF
Alzheimer's Disease	39.74	References/Inference Genes References Inference genes 21715663 23047022 12852432 19734902 18227305 7596406 18675847 15622541 27117003 17962197 25714973 14517953 21460841 17344400 18077176 19734903 11144356 17409235 17573346 11470324 19374891 17192785 22944069 16651627 20157255 25352456 22507317 15732116 16449385 15750215 ACHE BAX BCL2 BDNF CALM1 CASP3 CLU ENO1 GSK3B HMOX1 IGF1 IL1B MAPT MTHFR PSEN1 SOD2 TNF VEGFA
Nerve Degeneration	37.76	References/Inference Genes References Inference genes 19740541 19911010 20385067 11146106 19686240 15153526 17967740 8921280 12871582 17581637 23106139 18206288 9710261 19457078 8978711 23437309 19741132 19243126 14999069 9452187 17687034 16307444 22921461 15372491 19522546 21039522 24885036 17005863 10203697 ADORA1 BAK1 BAX BCL2 BDNF CASP3 DDIT4 IFNG IGF1 LRRK2 MAPK1 MAPK3 PARK2 PSEN1 SIRT1 SLC6A3 SNCA SOD1 SOD2 TH TNF
Brain Ischemia	37.59	References/Inference Genes References Inference genes 15060315 19429140 18628779 15756928 9236716 9778187 19922383 17564305 15829914 11756504 17394460 17901229 15534175 15737438 12531513 BDNF CASP3 CASP9 CAT CCL2 GPX1 IL1B MAPK1 MAPK3 MTHFR NFKB1 NOS2 SOD1 SOD2 STAT3 TNF
Colonic neoplasm	35.54	References/Inference Genes References Inference genes 18349538 19147571 15059925 12842827 21188121 20876807 16105666 17404573 19946270 21081470 16284371 20715105 15037631 12189186 10223192 18283038 19028472 25279216 10866311 18987561 BAK1 BAX BCL2 CCND1 CDKN1A IFNG IL1B MAP2K6 MTHFR MYC NFKB1 NOS2 PARK2 SOD2 STAT3 TNF VEGFA
Myocardial Ischemia	35.44	References/Inference Genes References Inference genes 16775501 16214533 15347709 14583313 14503966 9860779 CCL2 CCND1 GSTP1 HK1 HMOX1 IGF1 IL1B KDR NR4A1 PDHA1 PEBP1 SLC8A1 SOD2 TNF TXNRD1 VEGFA
Adenocarcinoma	34.38	References/Inference Genes References Inference genes 20729852 1733439 18058806 21472143 17418594 12907644 16142352 26432044 19028472 15378696 6280079 BCL2 CASP8 CCND1 CYP2E1 ENO1 IL1B KDR MTOR MYC NFKB1 PLCE1 PRL SOD2 STAT3 TGFB1 TNF VEGFA
Carcinoma, Non-Small-Cell Lung	34.27	References/Inference Genes References Inference genes 24688052 22684020 16862215 21549414 11731445 17094902 21479364 16142352 15956251 20471133 26482881 9865924 CASP8 CAT CYP2E1 ENO1 GSTP1 KIT MYC NFE2L2 NQO1 PRDX1 RAF1 SOD2 STAT3 UCHL1 VEGFA
Parkinson's disease	32.86	References/Inference Genes References Inference genes 25064009 22043175 22355530 15882845 16510128 20664293 15099020 15824117 12151787 8558425 15198987 17388990 14535945 23628791 18353766 21892157 17131421 23721876 23472874 21318773 23017109 16573651 25279756 25631236 12732244 19915576 16963468 20711177 22166454 18322262 16353238 20205471 17188257 19946270 19276553 19590691 18841091 17690948 21245015 24833599 12588799 22185909 9763484 17190945 16112329 22110584 25149416 25106480 12885775 17010972 22841634 19915575 24582596 11535288 17005863 BDNF CYP2E1 DDIT4 DRD2 GPX1 GSTA4 GSTP1 HMOX1 LRRK2 MAPT NQO1 PARK2 SLC6A3 SNCA SOD1 SOD2 TNF
Hepatocellular carcinoma	32.28	References/Inference Genes References Inference genes 10629087 26189965 16127164 27022031 16767786 15341023 15565109 12029619 21147110 18666234 19731237 15162526 25822088 18760346 9029167 22561517 22649188 23242368 19919837 11509945 21472284 ACO2 BCL2L1 CASP8 CCND1 CYP1A1 CYP2E1 E2F1 ENO1 FOS GSTP1 HSPA5 IRS2 MTOR MYC NFE2L2 SOD2 STAT4 TGFB1 TH TNF UCHL1
Reperfusion Injury	31.71	References/Inference Genes References Inference genes 8215636 10706834 17906103 10594344 16682413 23075401 16397181 25780291 16971220 23061969 17660127 16968891 23875703 10383581 16982915 19193722 19917352 12024109 7922267 18460982 15364863 17112405 12352873 19058328 12468449 23743330 15449323 21940958 15829914 19673871 16526316 BCL2 CASP3 CASP8 CAT CCL2 CDKN1A FOS GPX1 HMOX1 IL1B KDR NOS2 SOD1 SOD2 STAT3 TNF
Radiation Injuries, Experimental	30.9	References/Inference Genes References Inference genes 11121210 22247605 20726721 IFNG IL1B MAPK1 MAPK3 SOD1 SOD2 TNF
Liver Cirrhosis, Experimental	30.03	References/Inference Genes References Inference genes 23341968 16610050 18458672 15996030 17347453 16496349 15650968 15745444 25380136 26806094 15492853 18416461 16953842 16025519 15591519 15772939 26435214 12389079 12586293 17072980 16085334 16579972 21163135 18380797 ACHE ALDH2 CASP7 CCL2 CDKN1A CYP1A2 FOS FXYD6 GNGT2 GSTA3 HMOX1 IFNG IGF1 IL1B LIMK2 MYC NFE2L2 NOS2 NRG1 PDGFRA RTN4 SIRT1 TGFB1 TNF VEGFA
Status Epilepticus	29.72	References/Inference Genes References Inference genes 19490431 18455351 16679645 20888801 20034406 18096215 8821376 15752349 17383094 8635431 18695509 20149694 17533168 18587450 16600505 20971094 18988310 18949272 16696126 18571097 7984056 15245787 BDNF CASP3 CASP8 CAT CCL2 FOS HMOX1 KCNMA1 MEF2C NOS2 NTRK2 PTK2B SLC8A1 TNF VEGFA

Definition

Description

Top Gene Interactions

Related Pathways

Maneb Health Effects

General Information

Mechanism of Action

Maneb Interacts with Diseases

Maneb Interacts with Genes

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Maneb

Definition

Description

Top Gene Interactions

Related Pathways

Maneb Health Effects

General Information

Mechanism of Action

Maneb Interacts with Diseases

Maneb Interacts with Genes

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

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Interactions list

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