MANEB

Definition

Manganese derivative of ethylenebisdithiocarbamate. It is used in agriculture as a fungicide and has been shown to cause irritation to the eyes, nose, skin, and throat. Fungicide esp. for protection of potatoes and tomatoes

Description

Maneb is a foliate fungicide and is a polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand to control a wide range of diseases including blight, leaf spot, rust, downy mildew and scab. Its mode of action is non-specific with protective action.

Top Gene Interactions

Related Pathways

Maneb Health Effects

Neurotoxic

General Information

Uses/Sources: This is a man-made compound that is used as a pesticide.

Mechanism of Action

Target Name	Mechanism of Action	References
Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Retinoic acid receptor alpha Receptor-type tyrosine-protein phosphatase beta Receptor-type tyrosine-protein phosphatase F Receptor-type tyrosine-protein phosphatase mu Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 13 Tyrosine-protein phosphatase non-receptor type 4 Tyrosine-protein phosphatase non-receptor type 9 Nuclear receptor subfamily 1 group I member 2 Mu-type opioid receptor Epidermal growth factor receptor Vascular endothelial growth factor receptor 3 RAC-alpha serine/threonine-protein kinase Casein kinase II subunit alpha Bile salt sulfotransferase Interleukin-1 alpha Cytochrome P450 2C19 Urokinase plasminogen activator surface receptor Nuclear receptor subfamily 1 group I member 3 Urokinase-type plasminogen activator Interstitial collagenase Nociceptin receptor Dual specificity protein phosphatase 3 Receptor-type tyrosine-protein phosphatase C P2Y purinoceptor 1 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Tyrosine-protein kinase ABL1 Low molecular weight phosphotyrosine protein phosphatase RAC-beta serine/threonine-protein kinase Aurora kinase A Vascular endothelial growth factor receptor 1 Tyrosine-protein kinase Fyn Glycogen synthase kinase-3 beta Insulin-like growth factor 1 receptor MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 5 Serine/threonine-protein kinase MARK1 Serine/threonine-protein kinase Nek2 Serine/threonine-protein kinase PAK 4 5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase Ribosomal protein S6 kinase alpha-5 Serine/threonine-protein kinase Sgk1 Proto-oncogene tyrosine-protein kinase Src Angiopoietin-1 receptor Tyrosine-protein kinase BTK Cyclin-dependent kinase 2 Dual specificity tyrosine-phosphorylation-regulated kinase 1B		23611293

Maneb Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Diabetes Mellitus, Experimental	67.34	References/Inference Genes References Inference genes 21340626 17177138 20709041 19804535 16380483 12123627 25808216 22342832 19478208 15855331 22138235 21505870 18603373 23458895 20654064 23792339 24513509 24632065 21757225 22191573 16123366 18375438 12193562 16959961 20388520 23090186 BAX BCL2 BCL2L1 CASP3 CAT CHRM2 CYP1A1 FAS GPX1 HK1 HMOX1 IFNG IGF1 IL1B IRS2 MFGE8 NEUROD1 NOS2 NQO1 PAX6 SERPINE1 SIRT1 SOD1 SOD2 TGFB1 TNF VEGFA
Breast carcinoma	60.12	References/Inference Genes References Inference genes 25322848 15665820 19756960 25267515 16777985 23535733 14975756 15601643 21466612 17634480 17965603 19636701 23621182 21127199 12432273 18398872 23839043 19617202 23180569 16954440 15631943 19446661 16792888 23063927 18511948 17516992 12517783 20135347 17520698 17450141 20941507 20562527 19655245 19385967 14672398 16583263 22572619 19839049 12839951 21036696 17255770 17595805 16298037 12810669 20948315 20228224 17293864 ACHE AKT1 BAX BCL2 BMP2 BMP4 CASP7 CASP8 CAT CCND1 CYP1A1 DAP3 DLL1 E2F1 ENO1 FOS GPX1 GPX4 GSTP1 HEY2 HEYL HMOX1 HSP90AA1 HSPA1B IFNG IGF1 IL1B KDR KIT MDM4 MFGE8 MTHFR NOS2 NQO1 NRG1 RAF1 SIRT1 SOD2 STAT3 TNF
Prostatic Neoplasms	50.13	References/Inference Genes References Inference genes 16465378 19593445 17173048 15159307 14975756 11196146 17199135 17465268 17919073 25246272 15302576 17013881 12893367 12771559 22564066 17148459 24763052 20356562 16908180 18082198 19074884 17606477 16421604 19208208 15538743 20124447 16427044 15682402 22581815 12727815 23315858 25970160 23441843 17542986 20052738 17507624 16733517 16172807 17646272 21062352 11275366 12592389 16606632 17967524 16931574 18829485 23704919 24586243 19223546 15598783 ACHE AKT1 BAD BAX BCL2 CASP9 CCND1 CDKN1A CLU CYP1A1 CYP2E1 GSK3B GSTP1 HMOX1 IGF1 ITPR1 LIFR MAPK3 MTHFR MYC NFE2L2 NQO1 PDHA1 PLAUR PRKCZ SERPINE1 SIRT1 SOD2 STAT3 TGFB1 VEGFA
Stomach Neoplasms	43.91	References/Inference Genes References Inference genes 17171786 22414649 25279216 21628965 20729852 14503839 21133646 19424620 1733439 14647439 26401016 18505952 21347786 23382965 10853026 15201584 16314833 21364753 17450141 16367923 21173787 19584167 17003101 15492468 22490514 15378696 BCL2L1 BDNF BMP2 CASP8 CCND1 CDKN1A ENO1 GSTP1 HMOX1 IL1B IRS2 MAPK1 MAPK3 MTHFR MYC PAX6 PDHA1 PLCE1 SERPINE1 SOD2 STAT3 TNF
Squamous cell carcinoma	40.76	References/Inference Genes References Inference genes 15557674 21401805 17566705 20852150 18572023 15956251 26432044 22072123 12543247 25199511 21351258 21472714 15274141 AKT1 CCL2 CCND1 CYP1A2 ENO1 GPX1 MAPK1 MAPK3 MYC NFE2L2 SIRT3 SOD2 STAT3 TGFB1 VEGFA
Diabetes Mellitus, Type 2	40.75	References/Inference Genes References Inference genes 15111504 16123366 23795780 12136229 15531508 23834033 24513509 17107852 23500658 16959961 22244987 BCL2 BCL2L1 CASP3 CASP8 CAT CYP1A2 FAS GPX1 HK1 HMOX1 IRS2 NEUROD1 NFKB1 NOS2 PAX6 SIRT1 SOD1 SOD2 TGFB1 TNF VEGFA
Lung Neoplasms	40.25	References/Inference Genes References Inference genes 15688187 11884234 18508827 25640678 22537621 16007126 1673675 17418594 11307925 12376484 11074608 12083368 17093202 22369883 17389614 14587096 12460898 21911043 26192916 11641043 22619562 12466968 19946270 7614408 17450141 22072123 12511591 16289808 17909032 11103801 AKT1 BCL2L1 CASP8 CCND1 CDKN1A CYP1A2 CYP2E1 FAS FOS GPX1 GSTP1 HMOX1 IFNG IL1B MAPK1 MAPK3 MTHFR MYC NOS2 PARK2 PRDX1 RAF1 TGFB1 TNF
Alzheimer's Disease	39.74	References/Inference Genes References Inference genes 19374891 7596406 20157255 25352456 21460841 12852432 18227305 19734903 16651627 16449385 18077176 15622541 15732116 23047022 11144356 19734902 22944069 21715663 17409235 18675847 17192785 27117003 17344400 11470324 25714973 17573346 15750215 14517953 17962197 22507317 ACHE BAX BCL2 BDNF CALM1 CASP3 CLU ENO1 GSK3B HMOX1 IGF1 IL1B MAPT MTHFR PSEN1 SOD2 TNF VEGFA
Nerve Degeneration	37.76	References/Inference Genes References Inference genes 11146106 15372491 8921280 17687034 21039522 17967740 8978711 19686240 23437309 19741132 22921461 9710261 23106139 18206288 20385067 16307444 15153526 19243126 24885036 19457078 19522546 17581637 14999069 9452187 12871582 17005863 19740541 10203697 19911010 ADORA1 BAK1 BAX BCL2 BDNF CASP3 DDIT4 IFNG IGF1 LRRK2 MAPK1 MAPK3 PARK2 PSEN1 SIRT1 SLC6A3 SNCA SOD1 SOD2 TH TNF
Brain Ischemia	37.59	References/Inference Genes References Inference genes 15737438 15060315 15829914 9236716 17394460 17564305 15756928 15534175 12531513 18628779 9778187 19429140 19922383 17901229 11756504 BDNF CASP3 CASP9 CAT CCL2 GPX1 IL1B MAPK1 MAPK3 MTHFR NFKB1 NOS2 SOD1 SOD2 STAT3 TNF
Colonic neoplasm	35.54	References/Inference Genes References Inference genes 18349538 20715105 19028472 17404573 15059925 19946270 25279216 10223192 12842827 10866311 16284371 16105666 15037631 19147571 18987561 12189186 21188121 21081470 20876807 18283038 BAK1 BAX BCL2 CCND1 CDKN1A IFNG IL1B MAP2K6 MTHFR MYC NFKB1 NOS2 PARK2 SOD2 STAT3 TNF VEGFA
Myocardial Ischemia	35.44	References/Inference Genes References Inference genes 14583313 16775501 9860779 16214533 15347709 14503966 CCL2 CCND1 GSTP1 HK1 HMOX1 IGF1 IL1B KDR NR4A1 PDHA1 PEBP1 SLC8A1 SOD2 TNF TXNRD1 VEGFA
Adenocarcinoma	34.38	References/Inference Genes References Inference genes 19028472 18058806 16142352 6280079 1733439 17418594 26432044 20729852 12907644 21472143 15378696 BCL2 CASP8 CCND1 CYP2E1 ENO1 IL1B KDR MTOR MYC NFKB1 PLCE1 PRL SOD2 STAT3 TGFB1 TNF VEGFA
Carcinoma, Non-Small-Cell Lung	34.27	References/Inference Genes References Inference genes 9865924 16862215 21479364 16142352 24688052 26482881 15956251 21549414 17094902 11731445 20471133 22684020 CASP8 CAT CYP2E1 ENO1 GSTP1 KIT MYC NFE2L2 NQO1 PRDX1 RAF1 SOD2 STAT3 UCHL1 VEGFA
Parkinson's disease	32.86	References/Inference Genes References Inference genes 25149416 25279756 23017109 16112329 21318773 20664293 21892157 8558425 25106480 24833599 16573651 20711177 15882845 22841634 20205471 25064009 17690948 22355530 25631236 19276553 12588799 23628791 17010972 12732244 19946270 17190945 16353238 15824117 17388990 18322262 24582596 22185909 23472874 16963468 11535288 22166454 17131421 19915576 23721876 14535945 12151787 12885775 18841091 17005863 19590691 9763484 15099020 22043175 18353766 22110584 17188257 15198987 21245015 16510128 19915575 BDNF CYP2E1 DDIT4 DRD2 GPX1 GSTA4 GSTP1 HMOX1 LRRK2 MAPT NQO1 PARK2 SLC6A3 SNCA SOD1 SOD2 TNF
Hepatocellular carcinoma	32.28	References/Inference Genes References Inference genes 19731237 27022031 12029619 21472284 15565109 16767786 10629087 21147110 9029167 22561517 23242368 25822088 19919837 11509945 22649188 18666234 26189965 15341023 15162526 18760346 16127164 ACO2 BCL2L1 CASP8 CCND1 CYP1A1 CYP2E1 E2F1 ENO1 FOS GSTP1 HSPA5 IRS2 MTOR MYC NFE2L2 SOD2 STAT4 TGFB1 TH TNF UCHL1
Reperfusion Injury	31.71	References/Inference Genes References Inference genes 19058328 15449323 16526316 15364863 16682413 10594344 10706834 19673871 19917352 17906103 10383581 12352873 23743330 16971220 12468449 19193722 7922267 16968891 23061969 12024109 17112405 16397181 17660127 18460982 15829914 25780291 23075401 8215636 16982915 21940958 23875703 BCL2 CASP3 CASP8 CAT CCL2 CDKN1A FOS GPX1 HMOX1 IL1B KDR NOS2 SOD1 SOD2 STAT3 TNF
Radiation Injuries, Experimental	30.9	References/Inference Genes References Inference genes 20726721 22247605 11121210 IFNG IL1B MAPK1 MAPK3 SOD1 SOD2 TNF
Liver Cirrhosis, Experimental	30.03	References/Inference Genes References Inference genes 15591519 23341968 16610050 16579972 17072980 17347453 18380797 18458672 12586293 26806094 26435214 15745444 18416461 12389079 15492853 15650968 16953842 21163135 16496349 25380136 16025519 15996030 16085334 15772939 ACHE ALDH2 CASP7 CCL2 CDKN1A CYP1A2 FOS FXYD6 GNGT2 GSTA3 HMOX1 IFNG IGF1 IL1B LIMK2 MYC NFE2L2 NOS2 NRG1 PDGFRA RTN4 SIRT1 TGFB1 TNF VEGFA
Status Epilepticus	29.72	References/Inference Genes References Inference genes 18988310 18587450 17383094 20149694 16679645 8821376 15752349 16600505 20034406 18949272 17533168 18455351 18695509 20888801 18096215 18571097 8635431 16696126 15245787 19490431 7984056 20971094 BDNF CASP3 CASP8 CAT CCL2 FOS HMOX1 KCNMA1 MEF2C NOS2 NTRK2 PTK2B SLC8A1 TNF VEGFA

Definition

Description

Top Gene Interactions

Related Pathways

Maneb Health Effects

General Information

Mechanism of Action

Maneb Interacts with Diseases

Maneb Interacts with Genes

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Maneb

Definition

Description

Top Gene Interactions

Related Pathways

Maneb Health Effects

General Information

Mechanism of Action

Maneb Interacts with Diseases

Maneb Interacts with Genes

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

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Interactions list

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