Definition
One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids; Loperamide usually as hydrochloride, is a drug effective against diarrhea resulting from gastroenteritis or inflammatory bowel disease. In most countries it is available generically under brand names such as Lopex, Imodium, Dimor and Pepto Diarrhea Control; Treatment should be avoided in the presence of fever or if the stool is bloody. Treatment is not recommended for patients who could suffer detrimental effects from rebound constipation. If there is a suspicion of diarrhea associated with organisms that can penetrate the intestinal walls, such as E. coli O157:H7 or salmonella, loperamide is contraindicated; Loperamide, usually as hydrochloride, is a drug effective against diarrhea resulting from gastroenteritis or inflammatory bowel disease. In most countries it is available generically under brand names such as Lopex, Imodium, Dimor and Pepto Diarrhea Control; it does not affect the central nervous system like other opioids; One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally; Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines [HMDB]
Top Gene Interactions
Related Pathways
Loperamide Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Kidney Neoplasms | 14.9 |
|
Infertility, Female | 12.08 |
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Drug-induced liver injury | 11.0 |
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Neoplasm Metastasis | 10.89 |
|
Pneumonia, Pneumococcal | 10.49 |
|
Cocaine dependence | 10.38 |
|
Ceroid Lipofuscinosis, Neuronal, 6 | 10.23 |
|
Radiation Injuries, Experimental | 9.8 |
|
Brain Ischemia | 9.59 |
|
Trigeminal Neuralgia | 9.19 |
|
Hepatitis, Autoimmune | 9.0 |
|
Leukemia-Lymphoma, Adult T-Cell | 8.79 |
|
Gliosis | 8.33 |
|
Cardiomyopathies | 8.21 |
|
Metabolic Syndrome X | 7.79 |
|
Head and Neck Neoplasms | 7.66 |
|
Liver Neoplasms | 7.52 |
|
Liver Cirrhosis, Experimental | 7.47 |
|
Lung Neoplasms | 6.93 |
|
Hyperalgesia | 6.89 |
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