Top Gene Interactions
- Metabolism: Hepatic. Route of Elimination: About 45% of levonorgestrel and its metabolites are excreted in the urine and about 32% are excreted in feces, mostly as glucuronide conjugates.
- Uses/Sources: For the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.
- Route of Exposure: Levonorgestrel is not subjected to a "first-pass" effect and is virtually 100% bioavailable.
- Carcinogenicity: Norgestrel: Group 2B, possibly carcinogenic to humans. (L135)
- Toxicity: LD50 >5000 mg/kg (orally in rats)
Mechanism of Action
|Target Name||Mechanism of Action||References|
Nuclear receptor subfamily 1 group I member 2
Cytochrome P450 2C19
3-oxo-5-alpha-steroid 4-dehydrogenase 1