Definition
Description
L-Histidine is Found in These Foods
L-Histidine Health Effects
General Information
- Uses/Sources: The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
- Route of Exposure: Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: ORL-RAT LD<sub>50</sub> > 15000 mg/kg, IPR-RAT LD<sub>50</sub> > 8000 mg/kg, ORL-MUS LD<sub>50</sub> > 15000 mg/kg, IVN-MUS LD<sub>50</sub> > 2000 mg/kg
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Sodium-coupled neutral amino acid transporter 3 Histidine decarboxylase Histidine--tRNA ligase, cytoplasmic Histidine ammonia-lyase Glutaminyl-peptide cyclotransferase |
16741232 17150756 17227057 17185227 17193285 17075268 17536021 15843493 17016423 16960050 17191019 17191848 16790022 14522962 17139284 |